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Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
TLDR
It is shown that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs, most likely the visual pigment of phototransducing R GCs that set the circadian clock and initiate other non–image-forming visual functions. Expand
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
TLDR
Staining patterns after monocular enucleation revealed that the projections of these cells are overwhelmingly crossed except for the projection to the SCN, which is bilaterally symmetrical, and that other ganglion cells do contribute at least some retinal input to these targets. Expand
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
TLDR
It is reported that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. Expand
Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice
TLDR
The rod–cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions such as pupillary light reflex and circadian photo-entrainment. Expand
Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision
TLDR
It is reported that ipRGCs are more abundant and diverse than previously appreciated, project more widely within the brain, and can support spatial visual perception. Expand
Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs
TLDR
It is found that molecularly distinct subpopulations of M1 ipRGCs, which are morphologically and electrophysiologically similar, innervate different brain regions to execute specific light-induced functions. Expand
Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision
TLDR
It is indicated that light signals for irradiance detection are dissociated from pattern vision at the retinal ganglion cell level, and animals that cannot detect light for NIF functions are still capable of image formation. Expand
Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions
TLDR
This review summarizes the current understanding of the diversity of ipRGCs and their various roles in modulating behavior. Expand
A Role for Melanopsin in Alpha Retinal Ganglion Cells and Contrast Detection
TLDR
It is shown that the ONalpha RGC, a conventional RGC type, is intrinsically photosensitive in mammals, and that mice lacking either melanopsin or ON alpha RGCs have behavioral deficits in contrast sensitivity. Expand
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
TLDR
It is shown, using an aberrant light cycle that neither changes the amount and architecture of sleep nor causes changes in the circadian timing system, that light directly regulates mood-related behaviours and cognitive functions in mice. Expand
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