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C-3 Epimerization of Vitamin D3 Metabolites and Further Metabolism of C-3 Epimers
The results indicate that C-3 epimerization may be a common metabolic pathway for the major metabolites of vitamin D3, particularly against human myeloid leukemia cells (HL-60). Expand
Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites
The enzyme responsible for the C-3 epimerization of Vitamin D3 are thought to be different from already-known cytochrome P450-related Vitamin D metabolic enzymes and HSE. Expand
Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]
In the induction of human myeloid leukemia cell differentiation, inhibition of the human histiocytic lymphoma cell proliferation, and increase in osteocalcin concentration in the human osteosarcoma cell (MG-63), 20-epi-eldecalcitol showed significantly enhanced activity compared to eldecalCitol. Expand
Measurement and characterization of C-3 epimerization activity toward vitamin D3.
The enzyme(s) responsible for the epimerization of vitamin D(3) at C-3 are thought to be located in microsomes and different from cytochrome P450 and HSE. Expand
The Mechanism of Substrate Recognition of Pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as Determined by X-ray Crystallography and Site-directed Mutagenesis*
Pyroglutamyl-peptidase is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases. To clarify the mechanism of substrate recognitionExpand
Novel inhibitor for prolyl aminopeptidase from Serratia marcescens and studies on the mechanism of substrate recognition of the enzyme using the inhibitor.
Novel inhibitors of Pro, Ala, and Sar having 2-tert-butyl-[1,3,4]oxadiazole (TBODA) were synthesized and indicated that the molecular recognition of proline is achieved through four electrostatic interactions and an insertion in the hydrophobic pocket of the enzyme. Expand
Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24A1 ☆
Abstract The metabolism of 1α,25(OH) 2 D 3 (1α,3β) and its A-ring diastereomers, 1β,25(OH) 2 D 3 (1β,3β), 1α,25(OH) 2 -3-epi-D 3 (1α,3α), and 1β,25(OH) 2 -3-epi-D 3 (1β,3α), was examined to compareExpand
A new route to substituted 3-methoxycarbonyldihydropyrans; enantioselective synthesis of (–)-methyl elenolate
A stereoselective chiral synthesis of (–)-methyl elenolate has been achieved by employing a newly developed method for the construction of substituted 3-methoxycarbonyldihydropyrans based on aExpand