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Determination of simvastatin and its active metabolite in human plasma by column-switching high-performance liquid chromatography with fluorescence detection after derivatization with
This assay method has adequate sensitivity and selectivity to measure the concentrations of I and II in human plasma from clinical studies and is suitable for evaluating simvastatin and its active hydrolyzed metabolite in humans. Expand
High-performance liquid chromatographic determination of finasteride in human plasma using direct injection with column switching.
  • T. Takano, S. Hata
  • Chemistry, Medicine
  • Journal of chromatography. B, Biomedical…
  • 9 February 1996
A fully automated column-switching high-performance liquid chromatographic (HPLC) method was developed for the quantification of finasteride in human plasma and was validated and applied to the assay of plasma samples to characterize pharmacokinetic parameters in clinical studies. Expand
N‐(2‐Carboxyphenyl)‐4‐chloroanthranilic acid disodium salt: prevention of autoimmune kidney disease in NZB/NZW F1 hybrid mice
It is considered that agents activating the T-cell function might prevent the appearance of autoantibody and the development of autoimmune desease in B/W mice. Expand
Binding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitro.
Results indicate that human erythrocytes contain proteins that bind to dorzolamide and N-deethylated dorZolamide, and the binding of these proteins is saturable, suggesting that these compounds bind to the same binding site on CAs. Expand
In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice,
There appeared to be species differences in the metabolism of NB-506 in vitro, correlating well with the species-dependent pharmacokinetics of this drug in vivo, and this drug was glucuronized in mice, rats, and humans, but not in dogs. Expand
Simultaneous determination of a new anticancer agent (NB-506) and its active metabolite in human plasma and urine by high-performance liquid chromatography with ultraviolet detection.
A high-performance liquid chromatographic method with ultraviolet detection has been developed to quantify NB-506 and its active metabolite in human plasma and urine, thereby allowing the simultaneous measurement of the drug and metabolite with the limit of quantification of 0.01 microgram/ml in plasma and 0.1 microgram /ml in urine. Expand
N‐Carboxyphenyl)‐4‐chloroanthranilic acid disodium salt: a novel anti‐arthritic agent without anti‐inflammatory and immunosuppressive activities
A new type of anti-arthritic agent, N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium salt (CCA), which inhibits adjuvant arthritis in rats, in spite of its lack of both anti-inflammatory and immunosuppressive activities. Expand
Contraction of the Canine Basilar Artery following Linoleic, Arachidonic, 13-Hydroperoxylinoleic, or 15-Hydroperoxyarachidonic Acid
The maximal artery response to each of the hydroperoxy fatty acids was almost 1.4 times stronger than that obtained with serotonin, LA, or AA, and the cumulative dose–response contraction was approximately 400 times that of serotonin. Expand
A selected ion monitoring method for quantifying simvastatin and its acid form in human plasma, using the ferroceneboronate derivative.
Simvastatin, a pro-drug lactone, forms the open carboxylic acid as a major metabolite that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase and was independently converted into a 1,3-diol-type compound that gave satisfactory mass spectra for GC/MS/SIM measurements. Expand