• Publications
  • Influence
WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties.
TLDR
WF11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899 and showed good solubility in water. Expand
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
TLDR
It is shown that FR901469 inhibited the activity of 1,3-beta-glucan synthase from Candida albicans with an IC50 value of 0.05 microg/ml, and displayed greater inhibitory activity than other 1, 3- beta-gluca synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin A. Expand
Chemical diversity in lipopeptide antifungal antibiotics
In the course of screening for antifungal antibiotics, we have discovered a novel series of lipopeptide compounds structurally related to, but highly superior to, echinocandin B in terms of theirExpand
Micafungin: a sulfated echinocandin
  • S. Hashimoto
  • Chemistry, Medicine
  • The Journal of Antibiotics
  • 2009
Micafungin is the second approved antifungal agent in the echinocandin series and is now used worldwide in chemotherapy for life-threatening fungal infections. It is water-soluble and isExpand
FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
TLDR
The structure of FR109615 was elucidated as cis-2-aminocyclopentane-1-carboxylic acid and showed the excellent in vivo efficacy in a generalized infection test of mice. Expand
A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
TLDR
Structural studies on FR182877 suggested that it had a unique hexacyclic structure encompassing its highly strained double bond, which exhibited potent antitumor activities against murine ascitic tumor and solid tumor in vivo. Expand
FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties.
The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. TheExpand
FR900403, a new antifungal antibiotic produced by a Kernia sp.
TLDR
On etudie l'activite antifongique contre Candida albicans in vitro et chez des souris infectees. Expand
FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
TLDR
Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573 and showed antif fungus activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1-3-β-glucan synthesis. Expand
FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616
Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. TheseExpand
...
1
2
3
4
5
...