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Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling*
  • X. Li, Y. Zhang, +5 authors D. Wu
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 20 May 2005
The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found that sclerostin could antagonize canonical Wnt signaling in humanExpand
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Electromagnetically Induced Transparency
  • S. Harris
  • Materials Science
  • QELS '97., Summaries of Papers Presented at the…
  • 1 July 1997
Electromagnetically induced transparency is a technique for eliminating the effect of a medium on a propagating beam of electromagnetic radiation. EIT may also be used, but under more limitedExpand
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Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin*
Sclerostin, the protein product of the Sost gene, is a potent inhibitor of bone formation. Among bone cells, sclerostin is found nearly exclusively in the osteocytes, the cell type that historicallyExpand
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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
Human and mouse genetic and in vitro evidence has shown that canonical Wnt signaling promotes bone formation, but we found that mice lacking the canonical Wnt antagonist Dickkopf2 (Dkk2) wereExpand
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Ecological Genetics: Design, Analysis, and Application
Preface. Abbreviations. 1 Ecological Genetics. 2. Markers And Sampling In Ecological Genetics. 3. Genetic Diversity And Differentiation. 4. Gene Flow and Mating System. 5. Intraspecific PhylogeniesExpand
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E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation
ABSTRACT Within mineralized bone, osteocytes form dendritic processes that travel through canaliculi to make contact with other osteocytes and cells on the bone surface. This three-dimensionalExpand
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Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene.
Our previous studies have demonstrated that promoter-green fluorescent protein (GFP) transgenes can be used to identify and isolate populations of cells at the preosteoblastic stage (pOBCol3.6GFP)Expand
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Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro.
We have found that the ubiquitin-proteasome pathway exerts exquisite control of osteoblast differentiation and bone formation in vitro and in vivo in rodents. Structurally different inhibitors thatExpand
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Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
Functions of bone morphogenetic proteins (BMPs) are initiated by signaling through specific type I and type II serine/threonine kinase receptors. In previous studies, we have demonstrated that theExpand
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A model of transcriptional regulatory networks based on biases in the observed regulation rules
A statistical ensemble of networks with the observed canalizing bias presicts cells are in an ordered regime with convergent flow in transcription state space, a percolating subnetwork of genes fixed on or off an isolated islands of twinkling genes, and a near power-law distribution of cascades of gene activity changes following perturbations. Expand
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