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Analytical ultracentrifugation in biochemistry and polymer science
Part I: Instrumentation Part II: Equilibrium Methods Part III: Transport Methods Part IV: Specific Applications to Biochemical and Polymer Systems
UltraScan - A Comprehensive Data Analysis Software Package for Analytical Ultracentrifugation Experiments
The intrinsic viscosity of biological macromolecules. Progress in measurement, interpretation and application to structure in dilute solution.
- S. Harding
- Medicine, Chemistry
- Progress in biophysics and molecular biology
- 5 September 1997
The concentration-dependence of macromolecular parameters.
Theories concerning the concentration-dependence of sedimentation and diffusion coefficients for macro-molecules in dilute solution are compared and discussed, together with their experimental basis.… Expand
Polylactide−Poly(ethylene glycol) Copolymers as Drug Delivery Systems. 1. Characterization of Water Dispersible Micelle-Forming Systems
Copolymers of polylactide and poly(ethylene glycol) (PLA−PEG), which self-disperse in water to form spherical nonionic micelles, have been investigated as a novel biodegradable drug delivery system.… Expand
Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems.
Atomic force microscopy has been utilized to probe, at a molecular level, the interaction between purified pig gastric mucin (PGM) and a mucoadhesive cationic polymer, chitosan (sea cure 210+), with… Expand
Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes.
- A. Shevchuk, J. Gorelik, S. Harding, M. Lab, D. Klenerman, Y. Korchev
- Biology, Medicine
- Biophysical journal
- 1 September 2001
We have developed a distance modulated protocol for scanning ion conductance microscopy to provide a robust and reliable distance control mechanism for imaging contracting cells. The technique can… Expand
Rapid size distribution and purity analysis of gastric mucus glycoproteins by size exclusion chromatography/multi angle laser light scattering.
- K. Jumel, I. Fiebrig, S. Harding
- Chemistry, Medicine
- International journal of biological…
- 1 February 1996
The weight average molar masses and molar mass distributions of two commercial pig gastric mucins and two fresh mucin preparations were determined by the technique of size exclusion chromatography… Expand
Identification of a Flavin:NADH Oxidoreductase Involved in the Biosynthesis of Actinorhodin
- S. Kendrew, S. Harding, D. Hopwood, E. N. Marsh
- Biology, Medicine
- The Journal of Biological Chemistry
- 21 July 1995
The biosynthesis of the polyketide antibiotic actinorhodin by Streptomyces coelicolor involves the oxidative dimerization and hydroxylation of a precursor, most likely dihydrokalafungin, as the final… Expand
Genetic improvement of tomato by targeted control of fruit softening
- Selman Uluisik, N. Chapman, +26 authors G. Seymour
- Medicine, Biology
- Nature Biotechnology
- 1 September 2016
Controlling the rate of softening to extend shelf life was a key target for researchers engineering genetically modified (GM) tomatoes in the 1990s, but only modest improvements were achieved.… Expand