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KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis.
The mode of action of a novel compound, 3-isobutyryl-2-isopropylpyrazolo [1,5-a]pyridine (KC-404), as a potential anti-allergic agent has been investigated. KC-404 was shown to have a directExpand
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  • 1
Inhibition of antigen-induced contraction of guinea pig isolated tracheal muscle with 2-n-butyl-3-dimethylamino-5,6-methylenedioxy indene (MDI-A), indane (MDI-B) and
The effects of three intracellular calcium antagonists on antigen-induced contraction of sensitized guinea pig tracheal muscle were investigated. The agents employed were:Expand
  • 2
A method of inducing and recording cough and examination of the action of some drugs with this method.
  • S. Hara, S. Yanaura
  • Chemistry, Medicine
  • Japanese journal of pharmacology
  • 1 September 1959
pathological physiology and pharmacology of cough can be obtained by reading Bucher's article (1). The methods hitherto used for inducing cough are chemical stimulation (2-5), electrical stimulationExpand
  • 4
[Effects of KC-404 on bronchial anaphylactic reactions].
The effects of 3-isobutyryl-2-isopropylpyrazolo [1,5-a] pyridine (KC-404), a new anti-allergic agent with a unique mode of action, on bronchial anaphylactic reactions were investigated in guinea pigsExpand
  • 1
Pharmacological studies in the functions of the extrapyramidal system. I.
  • S. Hara
  • Medicine, Psychology
  • Japanese journal of pharmacology
  • 1 March 1953
It is a well-known fact that both morphologically and functionally the extrapyramidal system is extremely complex. In these studies of the system I have introduced pharmacological methods in anExpand
  • 16
[Effect of KC-404 on allergic reactions types I-IV].
The effects of 3-isobutyryl-2-isopropylpyrazolo [1,5-a] pyridine (KC-404), a new anti-allergic agent, on type I to IV allergic reactions were investigated. KC-404 administered orally inhibitedExpand
  • 4
Evaluation of anti-allergic effects of 1-substituted 2-n-butyl-methylenedioxy indenes.
The effects of ten 1-substituted 2-n-butyl-5,6-methylenedioxyindenes on mice and guinea pigs were investigated for their allergic reactions in the development of a new anti-allergic drug.Expand
On the species difference of the appearance of blood pressure action of lobeline in animals.
Tiara and his co-workers (1-6) have been carrying out pharmacological examination of lobeline for the past 30 years. In the present series of experiments, reexaminations were made on the action ofExpand
  • 2
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