Anti-HIV-1 reverse transcriptase activities of hexane extracts from some Asian medicinal plants
- K. Silprasit, Supaporn Seetaha, Parinya Pongsanarakul, S. Hannongbua, K. Choowongkomon
- Chemistry, Biology
- 9 September 2011
Anti-HIV agents, HIV-1 reverse transcriptase, inhibitor screening, PicoGreen, hexane extracts of Asian medicinal plants contained potent activity against HIV- 1 RT, with efficiency reported as 50% inhibitory concentrations.
Competitive inhibition of the dengue virus NS3 serine protease by synthetic peptides representing polyprotein cleavage sites.
- S. Chanprapaph, P. Saparpakorn, G. Katzenmeier
- BiologyBiochemical and Biophysical Research…
- 20 May 2005
Elucidating the origin of the esterase activity of human serum albumin using QM/MM calculations.
- Oraphan Phuangsawai, S. Hannongbua, M. P. Gleeson
- Biology, ChemistryJournal of Physical Chemistry B
- 7 October 2014
The results suggest Lys199, His242, and Arg257 help give rise to the esterase activity and that the most catalytically efficient active site configuration requires that both Lys199 and Aspirin are in their neutral forms.
In-silico ADME models: a general assessment of their utility in drug discovery applications.
- M. Gleeson, A. Hersey, S. Hannongbua
- BiologyCurrent Topics in Medicinal Chemistry
- 31 January 2011
This review considers how in-silico predictions of ADME processes can be used to help bias medicinal chemistry into more ideal areas of property space, minimizing the number of compounds needed to be synthesized to obtain the required biochemical/physico-chemical profile.
Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture.
- Hui Ming Ge, Wei Yun Zhang, R. Tan
- ChemistryChemical Communications
- 20 November 2008
Two azaphilone alkaloid dimers with an unprecedented skeleton were characterized from an endophytic fungus Chaetomium globosum with the former ascertained to be a significant cytotoxin valuable for anti-tumor drug discovery.
Chevalone C analogues and globoscinic acid derivatives from the fungus Neosartorya spinosa KKU-1NK1.
- Oue-Artorn Rajachan, K. Kanokmedhakul, S. Kanokmedhakul
- Chemistry, BiologyPhytochemistry
- 1 December 2016
Simple and rapid determination of the enzyme kinetics of HIV-1 reverse transcriptase and anti-HIV-1 agents by a fluorescence based method.
- K. Silprasit, Ratsupa Thammaporn, Supanna Tecchasakul, S. Hannongbua, K. Choowongkomon
- Biology, ChemistryJournal of Virological Methods
- 1 February 2011
Insight into crucial inhibitor–enzyme interaction of arylamides as novel direct inhibitors of the enoyl ACP reductase (InhA) from Mycobacterium tuberculosis: computer-aided molecular design
- A. Punkvang, P. Saparpakorn, S. Hannongbua, P. Wolschann, H. Berner, P. Pungpo
- Chemistry, Biology
- 6 August 2010
A thorough investigation of the arylamide binding modes with InhA provided ample information about structural requirements for appropriate inhibitor–enzyme interactions thus offering guidelines for syntheses of novel analogs with enhanced biological activity.
Oligostilbenoids with Acetylcholinesterase Inhibitory Activity from Dipterocarpus alatus
- Chao-Jun Chen, Rong Jiang, R. Tan
- ChemistryPlanta Medica
- 15 October 2014
The discovery of compound 3 gave the first evidence that the biosynthetic origin of resveratrol aneuploids is related to the loss of a half resver atrol unit by oxidative cleavage.
Simulation Study of Interactions Between Two Bioactive Components from Zingiber cassumunar and 5-Lipoxygenase
- Kulpavee Jitapunkul, O. Poachanukoon, S. Hannongbua, P. Toochinda, L. Lawtrakul
- Chemistry, BiologyCellular and Molecular Bioengineering
- 1 February 2018
This work indicated that Compound D and DMPBD are competitive inhibitors, which are able to bind at the same 5-LO substrate binding site, which reveals opportunities for using these compounds as novel antiasthmatic drugs.