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The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues.
The human CEA family has been fully characterized. It comprises 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup. CEA is anExpand
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Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig ileum to contract. The response was reversed by the SRS antagonist FPLExpand
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Precipitation and carbohydrate-binding specificity studies on wheat germ agglutinin.
The ability of wheat germ agglutinin to form precipitates with a series of synthetic carbohydrate-protein conjugates and with carcinoembryonic antigen and its Smith degradation products wasExpand
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The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the
The human pregnancy-specific glycoprotein (PSG) genes belong to the carcinoembryonic antigen (CEA) family, which in turn is a member of the immunoglobulin superfamily. We have analyzed a 700-kbExpand
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Is there a role for CEA in innate immunity in the colon?
Carcinoembryonic antigen (CEA) is a well known tumor marker associated with the progression of colorectal tumors. The CEA family of glycoproteins has been fully characterized and the function of someExpand
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Nature of the tumor-associated determinant(s) of carcinoembryonic antigen.
The carbohydrate moiety of carcinoembryonic antigen could be sequentially degraded by repeated cycles of periodate oxidation, reduction, and mild acid hydrolysis (Smith degradation). After threeExpand
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Specificity and affinity of 26 monoclonal antibodies against the CA 125 antigen: first report from the ISOBM TD-1 workshop. International Society for Oncodevelopmental Biology and Medicine.
The specificity of 26 monoclonal antibodies against the CA 125 antigen was investigated in two phases of the ISOBM TD-1 workshop. The binding specificity was studied using CA 125 immunoextracted byExpand
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Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen.
The binding specificities of 52 well-characterized monoclonal antibodies (Mabs) against carcinoembryonic antigen (CEA) from 12 different research groups were studied by immunohistochemistry andExpand
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Four Carcinoembryonic Antigen Subfamily Members, CEA, NCA, BGP and CGM2, Selectively Expressed in the Normal Human Colonic Epithelium, Are Integral Components of the Fuzzy Coat
To elucidate which of the seven transcriptionally active genes of the carcinoembryonic antigen (CEA) subfamily are expressed in human colon, we first examined mRNA expression using reverseExpand
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Monoclonal lymphocyte population in human plasma cell myeloma.
To identify monoclonal bone marrow-derived (B) lymphocytes in human myelomatosis specific rabbit antisera were produced against idiotypic specificities on IgG-κ myeloma proteins from three patients.Expand
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