The MAP2/Tau family of microtubule-associated proteins
Microtubule-associated proteins of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals and are best known for their microtubules-stabilizing activity and for proposed roles regulating microtubule networks in the axons and dendrites of neurons.
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus.
- T. Krucker, G. Siggins, S. Halpain
- BiologyProceedings of the National Academy of Sciences…
- 6 June 2000
The hypothesis that dynamic actin filaments participate in specific aspects of synaptic plasticity was investigated at the Schaffer-collateral-CA1 pyramidal cell synapse of mouse hippocampus and the results are consistent with a model in which dynamic actIn filaments play an essential role in the molecular mechanisms underlying the early maintenance phase of LTP.
Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin
The results indicate that the actin-mediated stability of synaptic structure is disrupted by intense glutamate receptor activity and that calcineurin blockers may be useful in preventing such destabilization.
Actin and microtubules in neurite initiation: are MAPs the missing link?
It is proposed that physical association might be involved in force-based interactions and spatial organization of the two networks during neurite initiation as well, and many signaling cascades that affect actin filaments are also involved in the regulation of microtubule dynamics, and vice versa.
The MAP1 family of microtubule-associated proteins
Both MAP1A and MAP1B are well known for their microtubule-stabilizing activity, but MAP1 proteins can also interact with other cellular components, including filamentous actin and signaling proteins.
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices
The results indicate that stimulation of NMDA receptors leads to the activation of a neuronal proteinosphatase, presumably the calcium-dependent phosphatase calcineurin, and show, in an intact cell preparation, that signal transduction in the nervous system can be mediated by protein dephosphorylation.
Development and regulation of dendritic spine synapses.
Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and…
Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system
- C. S. Barros, B. Calabrese, U. Müller
- Biology, PsychologyProceedings of the National Academy of Sciences
- 17 March 2009
It is concluded that ErbB2/B4-mediated NRG1 signaling modulates dendritic spine maturation, and that defects at glutamatergic synapses likely contribute to the behavioral abnormalities in Erb B2/ B4-deficient mice.
MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments
3D maps of microtubules fully decorated with MAP2c or tau suggest that the evolutionarily maintained differences observed in the repeat domain may be important for the specific targeting of different repeats to either α or β tubulin.
The Role of Microtubule-Associated Protein 2c in the Reorganization of Microtubules and Lamellipodia during Neurite Initiation
Detailed time-lapse analyses of cultured hippocampal neurons revealed that neurites emerge from segmented lamellipodia, which then gradually extend from the cell body to become nascent growth cones, which suggests that actin- and microtubule-rich structures are reorganized in a coordinated manner.