Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes.
- C. Gregory, K. Hamil, F. S. French
- Biology, MedicineCancer Research
- 15 December 1998
Investigation of human prostate cancer xenograft CWR22 found androgen regulation of alpha-enolase and alpha-tubulin as well as other unknown mRNAs, including Insulin-like growth factor binding protein-5, the homeobox gene Nkx 3.1, the AR coactivator ARA-70, and cell cycle genes Cdk1 and Cdk2 were androgen regulated in C WR22.
Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis.
- R. Richardson, P. Sivashanmugam, M. O'Rand
- BiologyGene
- 30 May 2001
Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression.
The molecular mechanisms underlying the pleiotropic effects of FSH were investigated by screening a plasmid cDNA library for clones hybridizing to FSH-regulated RNAs and revealed that 3 clones that hybridized to positively regulated RNAs have sequences similar to known or putative transcription regulating factors.
HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human.
- K. Hamil, P. Sivashanmugam, S. Hall
- BiologyEndocrinology
- 2000
It is revealed that the 0.9-kb messenger RNA (mRNA) is most abundant in human caput; there is much less of it in corpus and little in cauda; and testosterone replacement maintained HE2 mRNA 3- to 5-fold higher than castrate levels, indicating its androgen dependence.
Reversible Immunocontraception in Male Monkeys Immunized with Eppin
- M. O'Rand, E. E. Widgren, A. Jagannadha Rao
- Biology, MedicineScience
- 12 November 2004
This study demonstrates that effective and reversible male immunocontraception is an attainable goal and may be extended to humans.
Host defense proteins of the male reproductive tract.
- S. Hall, K. Hamil, F. S. French
- BiologyJournal of Andrology
- 10 September 2002
Through improved understanding of innate antimicrobial proteins, ways to mimic or enhance their activities are found to be possible.
Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis.
- J. Tan, S. Hall, F. S. French
- BiologyMolecular Endocrinology
- 2000
The results suggest that PIAS1 functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.
Cystatin 11: a new member of the cystatin type 2 family.
The calculated tertiary structure of CST11 reveals that the three regions corresponding to the protease inhibitory wedge of CST3 are similarly juxtaposed in CST11, consistent with protease inhibitor function.
Protein Inhibitors of Activated STAT Resemble Scaffold Attachment Factors and Function as Interacting Nuclear Receptor Coregulators*
- Jiann-an Tan, S. Hall, K. Hamil, G. Grossman, P. Petrusz, F. S. French
- BiologyJournal of Biological Chemistry
- 10 May 2002
It is reported here thatPIAS1 has characteristics of a scaffold attachment protein, and the interaction of PIAS1 with other members of the PIAS family suggests a transcription coregulatory mechanism involving a multicomponent PIAS nuclear scaffold.
Domain interactions between coregulator ARA(70) and the androgen receptor (AR).
- Zhong-xun Zhou, B. He, S. Hall, E. Wilson, F. S. French
- BiologyMolecular Endocrinology
- 1 February 2002
An ARA(70) motif required for androgen-dependent interaction with the AR-LBD is identified and it is demonstrated that ARA (70) can interact with the NH(2)-terminal and carboxyl-terminal regions of AR.
...
...