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Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.
5'AMP-activated protein kinase (AMPK) can be activated in response to cellular fuel depletion and leads to switching off ATP-consuming pathways and switching on ATP-regenerating pathways in many cellExpand
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Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.
The 5'AMP-activated protein kinase (AMPK) is stimulated by contractile activity in rat skeletal muscle. AMPK has emerged as an important signaling intermediary in the regulation of cell metabolismExpand
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The effects of AICAR on adipocyte differentiation of 3T3-L1 cells.
The AMP-activated protein kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), has been found to inhibit the differentiation of 3T3-L1 adipocytes, if added at an earlyExpand
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Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport.
In cells expressing only the Glut1 isoform of glucose transporters, we have shown that glucose transport is markedly stimulated in response to hypoxia or inhibition of oxidative phosphorylation,Expand
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AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.
The AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine protein kinase important for the responses to metabolic stress. It consists of a catalytic alpha subunit and twoExpand
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AMP-activated protein kinase kinase: detection with recombinant AMPK α1 subunit
Abstract The AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine protein kinase important for the responses to metabolic stress. It consists of a catalytic α subunit and twoExpand
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Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line.
The AMP-activated protein kinase (AMPK) plays an important role in fuel metabolism in exercising skeletal muscle and possibly in the islet cell with respect to insulin secretion. Some of theseExpand
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Glucose represses PPARαgene expression via AMP‐activated protein kinase but not via p38 mitogen‐activated protein kinase in the pancreatic β‐cell
Background:  Peroxisome proliferator‐activated receptor α (PPARα) regulates the expression of fatty acid metabolism genes and is thought to play a role in the regulation of insulin secretion andExpand
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