A DNA-damaging oxoaporphine alkaloid from Piper caninum.
- Ji Ma, S. H. Jones, R. Marshall, Randall K. Johnson, S. Hecht
- Biology, ChemistryJournal of Natural Products
- 1 July 2004
Bioassay-guided fractionation of an active organic extract of Piper caninum, using a sensitive yeast assay to monitor putative double-strand DNA-damaging activity, resulted in the isolation of the…
A coumarin from Mallotus resinosus that mediates DNA cleavage.
A crude extract prepared from roots of Mallotus resinosus exhibited significant Cu(2+)-dependent DNA strand scission activity and was thus selected for bioassay-guided fractionation. Scopoletin (1),…
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.
- V. S. Prakash Chaturvedula, Zhijie Gao, S. Hecht, S. H. Jones, D. Kingston
- Chemistry, BiologyJournal of Natural Products
- 1 November 2003
Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase beta resulted in the isolation of the new…
Luotonin A. A naturally occurring human DNA topoisomerase I poison.
- A. Çaǧır, S. H. Jones, Rong Gao, B. M. Eisenhauer, S. Hecht
- Biology, ChemistryJournal of the American Chemical Society
- 17 October 2003
It is demonstrated that lu serotonin A stabilizes the human DNA topoisomerase I-DNA covalent binary complex, affording the same pattern of cleavage as the structurally related topoisomersase I inhibitor camptothecin.
Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.
DNA damaging activity of ellagic acid derivatives.
Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity.
DNA topoisomerase I inhibitors from Rinorea anguifera.
A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission.
A crude CH(2)Cl(2)-MeOH extract prepared from Commiphora africana was found to mediate Cu(2+)-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was…