A DNA-damaging oxoaporphine alkaloid from Piper caninum.
- Ji Ma, S. H. Jones, R. Marshall, Randall K. Johnson, S. Hecht
- Biology, ChemistryJournal of Natural Products
- 1 July 2004
Bioassay-guided fractionation of an active organic extract of Piper caninum, using a sensitive yeast assay to monitor putative double-strand DNA-damaging activity, resulted in the isolation of the…
A coumarin from Mallotus resinosus that mediates DNA cleavage.
- Ji Ma, S. H. Jones, S. Hecht
- Biology, ChemistryJournal of Natural Products
- 12 August 2004
A crude extract prepared from roots of Mallotus resinosus exhibited significant Cu(2+)-dependent DNA strand scission activity and was thus selected for bioassay-guided fractionation. Scopoletin (1),…
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.
- V. S. Prakash Chaturvedula, Zhijie Gao, S. Hecht, S. H. Jones, D. Kingston
- Chemistry, BiologyJournal of Natural Products
- 1 November 2003
Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase beta resulted in the isolation of the new…
Luotonin A. A naturally occurring human DNA topoisomerase I poison.
- A. Çaǧır, S. H. Jones, Rong Gao, B. M. Eisenhauer, S. Hecht
- Biology, ChemistryJournal of the American Chemical Society
- 17 October 2003
It is demonstrated that lu serotonin A stabilizes the human DNA topoisomerase I-DNA covalent binary complex, affording the same pattern of cleavage as the structurally related topoisomersase I inhibitor camptothecin.
Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.
- Ji Ma, S. H. Jones, S. Hecht
- Biology, ChemistryBioorganic & Medicinal Chemistry
- 15 July 2004
DNA damaging activity of ellagic acid derivatives.
- Ya-ming Xu, Jing-Zhen Deng, S. Hecht
- ChemistryBioorganic & Medicinal Chemistry
- 1 April 2003
Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity.
- Shisheng Li, Zhijie Gao, Xizhi Feng, S. H. Jones, S. Hecht
- Biology, ChemistryBioorganic & Medicinal Chemistry
- 1 August 2004
DNA topoisomerase I inhibitors from Rinorea anguifera.
- Ji Ma, S. H. Jones, R. Marshall, Xihan Wu, S. Hecht
- BiologyBioorganic & Medicinal Chemistry Letters
- 1 February 2005
A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission.
- Ji Ma, S. H. Jones, S. Hecht
- ChemistryJournal of Natural Products
- 5 January 2005
A crude CH(2)Cl(2)-MeOH extract prepared from Commiphora africana was found to mediate Cu(2+)-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was…
Synthesis and biochemical properties of E-ring modified luotonin A derivatives.
- A. Çaǧır, S. H. Jones, B. M. Eisenhauer, Rong Gao, S. Hecht
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 3 May 2004
...
...