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A spectroscopic study of the haemin--human-serum-albumin system.
The interaction of haemin with human serum albumin has been reexamined. The absorption spectrum of the bound haem is identical with that of uncomplexed monomeric haemin in solution, and it isExpand
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Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel
Chemically modified phosphorothioate oligodeoxynucleotides (ODNs) have become critical tools for research in the fields of gene expression and experimental therapeutics. Bioanalytical assays wereExpand
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Theoretical and experimental studies of the effect of pressure on solute retention in liquid chromatography.
Pressure is often assumed to have a negligible influence on solute retention in liquid chromatography because of the small compressibility of the mobile and stationary phases. The range of pressuresExpand
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Flow-through sampling for electrophoresis-based microfluidic chips using hydrodynamic pumping.
This work presents a novel electrophoretic microchip design which is capable of directly coupling with flow-through analyzers for uninterrupted sampling. In this device, a 3 mm wide sampling channelExpand
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Plastic microchip electrophoresis for genetic screening: The analysis of polymerase chain reactions products of fragile X (CGG)n alleles
Clinical screening of abnormal chromosomes associated with fragile X syndrome (FXS) demands a high‐throughput method including DNA sizing and detection of the amplified products. This study is toExpand
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Liquid‐Chromatographic Determination of Antidysrhythmic Drugs: Procainamide, Lidocaine, Quinidine, Disopyramide, and Propranolol
Summary We present a method for the analysis of antidysrhythmic drugs [procainamide, acecainide (NAPA2), lidocaine, quinidine, disopyramide, N-desisopropyl disopyramide, and propranolol] in serum.Expand
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Increased serum carnitine concentration in renal insufficiency.
We measured serum carnitine in groups of patients with various diseases. The concentration was frequently above normal in patients with renal insufficiency. The clinical significance of such anExpand
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Analysis of DNA fragments by microchip electrophoresis fabricated on poly(methyl methacrylate) substrates using a wire‐imprinting method
Microfluidic devices were fabricated on poly(methyl methacrylate) (PMMA) substrate using two small‐diameter (79 μm) wires to create a cross impression in plastics softened by low‐temperature heating.Expand
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Lecithin depletion in hepatic microsomal membranes of rats fed on a choline-deficient diet.
Abstract Total, rough and smooth microsomes were isolated from the liver of rats fed on a choline-supplemented or a choline-deficient diet for 24 hr. Some of the preparations were subjected toExpand
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Plastic microchip electrophoresis for analysis of PCR products of hepatitis C virus.
BACKGROUND Electrophoresis on polymeric rather than glass microstructures is a promising separation method for analytical chemistry. Assays on such devices need to be explored to allow assessment ofExpand
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