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Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog.
Signals from the notochord/floor plate are necessary and sufficient to induce the development of ventrally derived oligodendroglia and appear to act by specifying the future fate(s) of neuroepithelial cells at the ventricular surface rather than by influencing the proliferation or differentiation of prespecified progenitor cells in the parenchyma of the cord. Expand
Multiple roles for FGF-3 during cranial neural development in the chicken.
FGF-3 disappears from boundary regions just prior to the loss of the morphological boundaries suggesting a boundary-associated function, and other sites of expression have been identified. Expand
The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons.
Branchial arch tissue may act as a target-derived factor that guides motor axons during development and is likely to be mediated partly by Hepatocyte Growth Factor, although a component of branchial arch-mediated growth promotion and chemoattraction was not blocked by anti-HGF antibodies. Expand
Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases
A novel role for Wnt proteins is demonstrated in guiding FBM neurons during their rostral to caudal migration in the hindbrain and in vivo evidence is provided that Wnt5a is a candidate to mediate this process. Expand
Patterning and axon guidance of cranial motor neurons
- S. Guthrie
- Biology, Medicine
- Nature Reviews Neuroscience
- 1 November 2007
The recent identification of genes that are mutated in human cranial dysinnervation disorders is now shedding light on the functional consequences of perturbations of cranial motor neuron development. Expand
Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain
In vitro evidence suggesting that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit is presented, and in vitro evidence showing thatSlit1 and Slit2 proteins are selective inhibitors and repellents for dorsally projections, but not for ventrally projecting, cranial motor axons is presented. Expand
Differential Expression of LIM Homeobox Genes among Motor Neuron Subpopulations in the Developing Chick Brain Stem
- A. Varela-Echavarría, S. Pfaff, S. Guthrie
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 1 October 1996
In 2- to 7-day chick embryos, it is found that genes of the LIM homeobox family are expressed differentially among cranial motor nuclei, consistent with a role of these transcription factors in determining neuronal phenotype and axonal pathfinding. Expand
A distinct developmental programme for the cranial paraxial mesoderm in the chick embryo.
These experiments demonstrate that depending on their initial rostrocaudal position, cranial paraxial mesoderm cells migrate to fill the core of specific branchial arches and imply that signals in the vicinity of the hindbrain and branchialArches act on migrating myogenic cells to influence their gene expression and developmental pathways. Expand
Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions
- S. Guthrie, I. Muchamore, A. Kuroiwa, H. Marshall, R. Krumlauf, A. Lumsden
- Biology, Medicine
- 12 March 1992
Hox-2.9 was expressed in the ectopic r4 as strongly as in the normal r4, whereas reciprocal grafts of future r2 to r4 position did not express Hox- 2.9, suggesting that Hox genes confer positional value. Expand
Human CHN1 Mutations Hyperactivate α2-Chimaerin and Cause Duane's Retraction Syndrome
It is concluded that α2-chimaerin has a critical developmental function in ocular motor axon pathfinding in DRS families by identifying causative heterozygous missense mutations in CHN1, a gene on chromosome 2q31 that encodes α2, a Rac guanosine triphosphatase–activating protein (RacGAP) signaling protein previously implicated in the pathfinding of corticospinal axons in mice. Expand