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Diabetes Mellitus and Pancreatic Cancer in a Population-Based Case-Control Study in the San Francisco Bay Area, California
Background: Diabetes has been postulated to be both a risk factor and a consequence of pancreatic cancer, but the degree of risk and associated clinical factors remain unclear. Methods: We conducted… Expand
Metabolism of loratadine and further characterization of its in vitro metabolites.
The present study demonstrated that in addition to CYP3A4 and CYP2D6, the metabolism of loratadine is also catalyzed by CYP1A1, CYP2C19, and to a lesser extent by CYP1A2, CYP2B6, CYP2C8, CYP2C9 and… Expand
Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety
Antihistamines are widely used to treat allergic rhinitis (AR) and chronic idiopathic urticaria (CIU) in adults and children. Desloratadine is a once-daily oral antihistamine with a favourable… Expand
Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. A systematic review and critical analysis.
BACKGROUND Patients with hepatitis C virus (HCV) are at increased risk for hepatocellular carcinoma. Although serum alpha-fetoprotein (AFP) is often used to detect hepatocellular carcinoma in… Expand
Failure Rates in the Hepatocellular Carcinoma Surveillance Process
Hepatocellular carcinoma (HCC) surveillance is underutilized among patients with cirrhosis. Understanding which steps in the surveillance process are not being conducted is essential for designing… Expand
Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.
PURPOSE Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist approved for the treatment of major depressive disorder in adults. Vilazodone seems to be metabolized primarily by the… Expand
Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial.
- Karen A. Frankwich, J. Egnatios, +5 authors A. Zarrinpar
- Clinical gastroenterology and hepatology : the…
- 1 September 2015
BACKGROUND & AIMS Many companies provide genetic tests for obesity-related polymorphisms (nutrigenetics) and make dietary recommendations for weight loss that are based on the results. We performed a… Expand
High‐risk patients with hematuria are not evaluated according to guideline recommendations
To determine whether high‐risk patients with hematuria receive evaluation according to guideline recommendations.
Plasma apolipoprotein L1 levels do not correlate with CKD.
- L. Bruggeman, J. O’Toole, +8 authors R. Kalayjian
- Journal of the American Society of Nephrology…
- 1 March 2014
Polymorphisms in APOL1 are associated with CKD, including HIV-related CKD, in individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is localized in kidney cells, but… Expand
Sperm-associated antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma.
Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiation and chemotherapy. Current therapies for RCC patients are inefficient due to the lack of diagnostic and therapeutic… Expand