S. Gunasekera

Publications128
h-index37
Citations4,163
Highly Influential Citations93
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Inhibition of marine biofouling by bacterial quorum sensing inhibitors
Seventy eight natural products from chemical libraries containing compounds from marine organisms (sponges, algae, fungi, tunicates and cyanobacteria) and terrestrial plants, were screened for the… Expand
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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
Computer-assisted structure analysis indicated (+)-discodermolide, a polyhydroxylated alkatetraene lactone marine natural product, was an antimitotic compound, and we confirmed this prediction.… Expand
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The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and…
The lactone-bearing polyhydroxylated alkatetraene (+)-discodermolide, which was isolated from the sponge Discodermia dissoluta, induces the polymerization of purified tubulin with and without… Expand
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Sarasinoside A1: a saponin containing amino sugars isolated from a sponge
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Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
A new polyhydroxylated lactone, discodermolide (1), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic… Expand
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Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determined… Expand
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Phylogenetic Inferences Reveal a Large Extent of Novel Biodiversity in Chemically Rich Tropical Marine Cyanobacteria
ABSTRACT Benthic marine cyanobacteria are known for their prolific biosynthetic capacities to produce structurally diverse secondary metabolites with biomedical application and their ability to form… Expand
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Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic…
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Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry.
Extracts of several cyanobacterial species collected from different marine and estuarine locations predominately in Florida (USA), with one sample each from Belize and Oman, were screened for their… Expand
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Phylogenetic and Chemical Diversity of Three Chemotypes of Bloom-Forming Lyngbya Species (Cyanobacteria: Oscillatoriales) from Reefs of Southeastern Florida
ABSTRACT The cyanobacterial genus Lyngbya includes free-living, benthic, filamentous cyanobacteria that form periodic nuisance blooms in lagoons, reefs, and estuaries. Lyngbya spp. are prolific… Expand
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