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Inhibition of marine biofouling by bacterial quorum sensing inhibitors
- S. Dobretsov, M. Teplitski, Mirko Bayer, S. Gunasekera, P. Proksch, V. Paul
- BiologyBiofouling
- 31 August 2011
TLDR
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
- E. ter Haar, R. Kowalski, B. Day
- BiologyBiochemistry
- 9 January 1996
TLDR
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and…
- R. Kowalski, P. Giannakakou, S. Gunasekera, R. Longley, B. Day, E. Hamel
- Biology, ChemistryMolecular pharmacology
- 1 October 1997
TLDR
Sarasinoside A1: a saponin containing amino sugars isolated from a sponge
- F. Schmitz, M. Ksebati, S. Gunasekera, S. K. Agarwal
- Chemistry
- 21 April 1988
Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
- S. Gunasekera, M. Gunasekera, R. Longley, G. Schulte
- Chemistry
- 1 August 1990
A new polyhydroxylated lactone, discodermolide (1), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic…
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
- A. Wright, Dorilyn A. Forleo, G. Gunawardana, S. Gunasekera, F. Koehn, O. Mcconnell
- Chemistry, Biology
- 1 July 1990
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determined…
Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic…
- S. Tsujii, K. Rinehart, M. Diaz
- Biology
- 1 November 1988
Phylogenetic Inferences Reveal a Large Extent of Novel Biodiversity in Chemically Rich Tropical Marine Cyanobacteria
- Niclas Engene, S. Gunasekera, W. Gerwick, V. Paul
- Environmental Science, BiologyApplied and Environmental Microbiology
- 11 January 2013
TLDR
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
- S. Gunasekera, P. McCarthy, J. Clardy
- Biology, ChemistryJournal of natural products
- 1999
TLDR
Plant anticancer agents. XIX Constituents of Aquilaria malaccensis.
- S. Gunasekera, A. Kinghorn, G. Cordell, N. Farnsworth
- ChemistryJournal of natural products
- 1 September 1981
TLDR
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