S. Gunasekera

Publications127
h-index37
Citations4,538
Highly Influential Citations85
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Inhibition of marine biofouling by bacterial quorum sensing inhibitors
TLDR
It is suggested that natural products with QS inhibitory properties can be used for controlling biofouling communities and to prevent microfOUling by one of the compounds screened in this study.
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
TLDR
Discodermolide arrests Burkitt lymphoma cells in mitosis and shows spectacular rearrangement of the microtubule cytoskeleton, including extensive microtubules bundling in breast carcinoma cells.
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and…
TLDR
It is demonstrated that discodermolide is a competitive inhibitor with [3H]paclitaxel in binding to tubulin polymer, with an apparent Ki value of 0.4 microM, and that these properties represent hypernucleation phenomena.
Sarasinoside A1: a saponin containing amino sugars isolated from a sponge
Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
A new polyhydroxylated lactone, discodermolide (1), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic…
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determined…
Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic…
Phylogenetic Inferences Reveal a Large Extent of Novel Biodiversity in Chemically Rich Tropical Marine Cyanobacteria
TLDR
The phylogenetic inferences of marine cyanobacterial strains responsible for over 100 bioactive secondary metabolites revealed an uneven taxonomic distribution, with a few groups being responsible for the vast majority of these molecules.
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
TLDR
A new discorhabdin analogue has been isolated from a deep-water marine sponge of the genus Batzella and inhibited the phosphat enzyme activity of calcineurin and the peptidase activity of CPP32 and showed in vitro cytotoxicity against P-388 and A-549 cell lines.
Plant anticancer agents. XIX Constituents of Aquilaria malaccensis.
TLDR
The stem bark of the Thai tree Aquilaria malaccensis has afforded 1,3-dibehenyl-2-ferulyl glyceride, which is novel, and 12-O-n-deca- 2, 4, 6-trienoylphorbol-13-acetate, a cytotoxic compound which was elucidated by their spectral and chemical parameters.
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