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Global cancer surgery: delivering safe, affordable, and timely cancer surgery.
Surgery is essential for global cancer care in all resource settings. Of the 15.2 million new cases of cancer in 2015, over 80% of cases will need surgery, some several times. By 2030, we estimate… Expand
Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent
Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five… Expand
Ethnic Differences in the Frequency of Prostate Cancer Susceptibility Alleles at SRD5A2 and CYP3A4
Objectives: Ethnic differences in prostate cancer incidence are well documented, with African-Americans having among the highest rates in the world. Ethnic differences in genotypes for genes… Expand
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP… Expand
Evaluation of prostate cancer characteristics in four populations worldwide.
- C. Zeigler-Johnson, H. Rennert, +7 authors T. Rebbeck
- The Canadian journal of urology
- 1 June 2008
INTRODUCTION Prostate cancer is common around the world, but rates of advanced disease differ substantially by race and geography. Although a major health issue, little is known about prostate cancer… Expand
A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta
- W. A. Cabral, A. M. Barnes, +12 authors J. Marini
- Biology, Medicine
- Genetics in Medicine
- 26 January 2012
Purpose:Deficiency of prolyl 3-hydroxylase 1, encoded by LEPRE1, causes recessive osteogenesis imperfecta (OI). We previously identified a LEPRE1 mutation exclusively in African Americans and… Expand
Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men
Prostate cancer is the most common cancer in men in developed countries and the leading cause of mortality in males in less developed countries. African ethnicity is one of the major risk factors for… Expand
Screening for Prostate Cancer by Digital Rectal Examination and PSA Determination in Senegal
Objectives. The goal of our study was to investigate the prevalence of prostate cancer in an unselected population of Senegalese men. Patients and Methods. We conducted the study over two years (2008… Expand
Evaluation of Group Genetic Ancestry of Populations from Philadelphia and Dakar in the Context of Sex-Biased Admixture in the Americas
Background Population history can be reflected in group genetic ancestry, where genomic variation captured by the mitochondrial DNA (mtDNA) and non-recombining portion of the Y chromosome (NRY) can… Expand
Population differences in the frequency of the agouti signaling protein g.8818a>G polymorphism.
- C. Zeigler-Johnson, S. Panossian, S. Gueye, M. Jalloh, D. Ofori-Adjei, P. Kanetsky
- Biology, Medicine
- Pigment cell research
- 1 April 2004
The role of agouti signaling protein (ASIP) in human pigmentation pathways is not definitively understood although its murine homologue regulates, in part, pheomelanogenesis. We have reported an… Expand