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Microsatellite instability in colorectal cancer—the stable evidence
Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to epigenetic silencing ofExpand
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Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
Approximately 130,000 cases of col ore eta I cancer (CRC) are diagnosed in the United States each year1, and about 15% of these have a hereditary component2,3. Two well-defined syndromes, familialExpand
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Statins and cancer prevention
Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have ledExpand
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). InExpand
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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
Dysfunction of the endoplasmic reticulum (ER) has been reported in a variety of human pathologies, including cancer. However, the contribution of the ER to the early stages of normal cellExpand
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Network modeling links breast cancer susceptibility and centrosome dysfunction.
Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms of cancer susceptibility and progression. Better understanding is also required of how mutations inExpand
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Genetic/familial high-risk assessment: breast and ovarian.
Names: Lauren Corduck; Ephrat Levy-Lahad, MD; Ranjit Manchanda, MD, MRCOG, PhD; Jill Stopfer, MS, LGC; Elizabeth Etkin-Kramer, MD, FACOG; Patricia Clark, MD; Danielle Shiller, DO; Robin StrausExpand
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Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome
Background: Although an increased cancer risk in Peutz-Jeghers syndrome is established, data on the spectrum of tumors associated with the disease and the influence of germ-line STK11/LKB1Expand
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Phenotype of Microsatellite Unstable Colorectal Carcinomas: Well‐Differentiated and Focally Mucinous Tumors and the Absence of Dirty Necrosis Correlate With Microsatellite Instability
&NA; The phenotypic markers of colorectal carcinomas with microsatellite instability have been widely studied and include mucinous or poor differentiation, prominent host response, a circumscribedExpand
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Incidence of initial local therapy among men with lower-risk prostate cancer in the United States.
BACKGROUND The frequently indolent nature of early-stage prostate cancer in older men and in men with low- or moderate-grade tumors and the demonstration that the survival benefits of radicalExpand
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