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Microsatellite instability in colorectal cancer—the stable evidence
Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to epigenetic silencing of… Expand
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
Approximately 130,000 cases of col ore eta I cancer (CRC) are diagnosed in the United States each year1, and about 15% of these have a hereditary component2,3. Two well-defined syndromes, familial… Expand
Statins and cancer prevention
Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led… Expand
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In… Expand
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
- C. Denoyelle, G. Abou-Rjaily, +10 authors M. Soengas
- Medicine, Biology
- Nature Cell Biology
- 1 October 2006
Dysfunction of the endoplasmic reticulum (ER) has been reported in a variety of human pathologies, including cancer. However, the contribution of the ER to the early stages of normal cell… Expand
Network modeling links breast cancer susceptibility and centrosome dysfunction.
Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms of cancer susceptibility and progression. Better understanding is also required of how mutations in… Expand
Genetic/familial high-risk assessment: breast and ovarian.
- M. Daly, J. Axilbund, +22 authors J. Weitzel
- Journal of the National Comprehensive Cancer…
Names: Lauren Corduck; Ephrat Levy-Lahad, MD; Ranjit Manchanda, MD, MRCOG, PhD; Jill Stopfer, MS, LGC; Elizabeth Etkin-Kramer, MD, FACOG; Patricia Clark, MD; Danielle Shiller, DO; Robin Straus… Expand
Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome
Background: Although an increased cancer risk in Peutz-Jeghers syndrome is established, data on the spectrum of tumors associated with the disease and the influence of germ-line STK11/LKB1… Expand
Phenotype of Microsatellite Unstable Colorectal Carcinomas: Well‐Differentiated and Focally Mucinous Tumors and the Absence of Dirty Necrosis Correlate With Microsatellite Instability
- J. Greenson, J. Bonner, +10 authors S. Gruber
- The American journal of surgical pathology
- 1 May 2003
&NA; The phenotypic markers of colorectal carcinomas with microsatellite instability have been widely studied and include mucinous or poor differentiation, prominent host response, a circumscribed… Expand
Incidence of initial local therapy among men with lower-risk prostate cancer in the United States.
- D. Miller, S. Gruber, B. Hollenbeck, J. Montie, J. Wei
- Journal of the National Cancer Institute
- 20 December 2006
BACKGROUND The frequently indolent nature of early-stage prostate cancer in older men and in men with low- or moderate-grade tumors and the demonstration that the survival benefits of radical… Expand