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Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology
In 1965, Sir Austin Bradford Hill published nine “viewpoints” to help determine if observed epidemiologic associations are causal. Expand
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Benzene and human health: A historical review and appraisal of associations with various diseases
Over the last century, benzene has been a well-studied chemical, with some acute and chronic exposures being directly associated with observed hematologic effects in humans and animals. Chronic heavyExpand
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An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protectingExpand
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Increased expansion and differentiation of cord blood products using a two-step expansion culture.
OBJECTIVE [corrected] The use of allogeneic cord blood (CB) products as a source of cellular support for patients receiving high-dose chemotherapy has been limited primarily to smaller children dueExpand
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Cryopreservation of stem cells using trehalose: evaluation of the method using a human hematopoietic cell line.
While stem cell cryopreservation methods have been optimized using dimethylsulfoxide (DMSO), the established techniques are not optimal when applied to unfertilized human embryonic cells. InExpand
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Aggressive Natural Killer Cell Leukemia: Report of a Chinese Series and Review of the Literature
Aggressive natural killer cell leukemia (ANKL) is a rare Epstein-Barr virus (EBV)-associated fulminating disease that is widely disseminated at diagnosis. Because of its typically extranodalExpand
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A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China
The frequency of subtypes of lymphoid neoplasms was determined in a prospective series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period. Diagnosis and classification wasExpand
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Chronic exposure to benzene results in a unique form of dysplasia.
Hematotoxicity following chronic benzene exposure has been recognized for over a century, although the mechanism remains unknown. We describe a novel form of bone marrow dysplasia in 23 workersExpand
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The TNF-alpha 238A polymorphism is associated with susceptibility to persistent bone marrow dysplasia following chronic exposure to benzene.
Chronic exposure to benzene can result in transient hematotoxicity (benzene poisoning, BP) or persistent bone marrow pathology including dysplasia and/or acute myeloid leukemia. We recently describedExpand
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Integrating WHO 2001-2008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): a case-case analysis of benzene exposure.
We characterized the prevalence of hematopoietic and lymphoid disease for 2923 consecutive patients presenting at 29 hospitals from August 2003 to June 2007. Diagnoses were made in our laboratoryExpand
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