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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like protein containingExpand
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Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Introduction In vivo imaging provides a window into the spatially complex, rapidly evolving physiology of the cell that structural imaging alone cannot. However, observing this physiology directlyExpand
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Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo
Cell divisions that create daughter cells of different sizes are crucial for the generation of cell diversity during animal development. In such asymmetric divisions, the mitotic spindle must beExpand
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Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows
Asymmetric cell divisions are essential for the development of multicellular organisms. To proceed, they require an initially symmetric cell to polarize. In Caenorhabditis elegans zygotes,Expand
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Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos
Asymmetric divisions are crucial for generating cell diversity; they rely on coupling between polarity cues and spindle positioning, but how this coupling is achieved is poorly understood. InExpand
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Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System
Patterning of Caenorhabditis elegans zygotes involves passive as well as active mechanisms. In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteinsExpand
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The Distribution of Active Force Generators Controls Mitotic Spindle Position
During unequal cell divisions a mitotic spindle is eccentrically positioned before cell cleavage. To determine the basis of the net force imbalance that causes spindle displacement in one-cellExpand
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Spindle Oscillations during Asymmetric Cell Division Require a Threshold Number of Active Cortical Force Generators
BACKGROUND Asymmetric division of the C. elegans zygote is due to the posterior-directed movement of the mitotic spindle during metaphase and anaphase. During this movement along theExpand
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Forces Driving Epithelial Spreading in Zebrafish Gastrulation
Embryonic Cell Sorting and Movement Differential cell adhesion has long been thought to drive cell sorting. Maître et al. (p. 253, published online 23 August) show that cell sorting in zebrafishExpand
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Apical migration of nuclei during G2 is a prerequisite for all nuclear motion in zebrafish neuroepithelia
Nuclei in the proliferative pseudostratified epithelia of vastly different organisms exhibit a characteristic dynamics – the so-called interkinetic nuclear migration (IKNM). Although these movementsExpand
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