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- Publications
- Influence
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
- Maria Grazia Roncarolo, S. Gregori, M. Battaglia, R. Bacchetta, K. Fleischhauer, Megan K. Levings
- Biology, Medicine
- Immunological reviews
- 1 August 2006
Summary: Interleukin‐10 (IL‐10)‐secreting T regulatory type 1 (Tr1) cells are defined by their specific cytokine production profile, which includes the secretion of high levels of IL‐10 and… Expand
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
- N. Gagliani, C. F. Magnani, +14 authors M. Roncarolo
- Biology, Medicine
- Nature Medicine
- 1 June 2013
CD4+ type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has… Expand
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.
- S. Gregori, D. Tomasoni, +5 authors M. Roncarolo
- Biology, Medicine
- Blood
- 12 August 2010
Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. Interleukin-10 (IL-10) is the crucial… Expand
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells.
- M. Levings, S. Gregori, E. Tresoldi, S. Cazzaniga, C. Bonini, M. G. Roncarolo
- Biology, Medicine
- Blood
- 1 February 2005
Dendritic cells (DCs) are specialized antigen-presenting cells that monitor the antigenic environment and activate naive T cells. The role of DCs is not only to sense danger but also to tolerize the… Expand
Tr1 cells: from discovery to their clinical application.
- M. Battaglia, S. Gregori, R. Bacchetta, M. Roncarolo
- Biology, Medicine
- Seminars in immunology
- 1 April 2006
Peripheral tolerance is mediated by multiple mechanisms such as anergy and/or active suppression of effector T cells by T regulatory (Tr) cells. Among the CD4(+) Tr cells, T regulatory type 1 cells… Expand
A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice.
- S. Gregori, N. Giarratana, S. Smiroldo, M. Uskoković, L. Adorini
- Medicine
- Diabetes
- 2002
Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, dominated by interleukin-12 (IL-12)-dependent Th1 cells, of the pancreatic islets, with… Expand
CD4+ regulatory T cells: mechanisms of induction and effector function.
- R. Bacchetta, S. Gregori, M. Roncarolo
- Biology, Medicine
- Autoimmunity reviews
- 1 November 2005
The main subsets of CD4+ regulatory T (Tr) cells are the CD4+ CD25+ Tr cells and the type 1 regulatory (Tr1) cells. Both subsets are essential for the maintenance of peripheral tolerance. CD4+ CD25+… Expand
Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells.
- E. Hauben, S. Gregori, +4 authors M. G. Roncarolo
- Biology, Medicine
- Blood
- 15 August 2008
VAF347 is a low-molecular-weight compound, which activates the aryl hydrocarbon receptor (AhR). Herein, we report that oral administration of a water-soluble derivative of VAF347 (VAG539) promotes… Expand
Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.
- M. G. Roncarolo, S. Gregori, R. Bacchetta, M. Battaglia
- Biology, Medicine
- Current topics in microbiology and immunology
- 2014
T regulatory Type 1 (Tr1) cells are adaptive T regulatory cells characterized by the ability to secrete high levels of IL-10 and minimal amounts of IL-4 and IL-17. Recently, CD49b and LAG-3 have been… Expand
The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
- S. Gregori, K. Goudy, M. G. Roncarolo
- Biology, Medicine
- Front. Immun.
- 29 December 2011
The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular… Expand