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Cancer Information Scanning and Seeking in the General Population
The amount of cancer-related information available in the media and other sources continues to increase each year. We wondered how people make use of such content in making specific health decisions.Expand
Whole-exome sequencing and clinical interpretation of formalin-fixed , paraffin-embedded tumor samples to guide precision cancer medicine
682 VOLUME 20 | NUMBER 6 | JUNE 2014 naTuRe medicine Translating whole-exome sequencing (WES) for prospective clinical use may have an impact on the care of patients with cancer; however, multipleExpand
Return of genomic results to research participants: the floor, the ceiling, and the choices in between.
As more research studies incorporate next-generation sequencing (including whole-genome or whole-exome sequencing), investigators and institutional review boards face difficult questions regardingExpand
Differences in information seeking among breast, prostate, and colorectal cancer patients: results from a population-based survey.
OBJECTIVE There is much research describing cancer patients' information needs and their use of the Internet, print media, and other sources to fulfill these needs. Yet little is known about whetherExpand
Carboplatin and paclitaxel with vs without bevacizumab in older patients with advanced non-small cell lung cancer.
CONTEXT A previous randomized trial demonstrated that adding bevacizumab to carboplatin and paclitaxel improved survival in advanced non-small cell lung cancer (NSCLC). However, longer survival wasExpand
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine
BackgroundThe diversity of clinical tumor profiling approaches (small panels to whole exomes with matched or unmatched germline analysis) may engender uncertainty about their benefits andExpand
Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas
Introduction: ALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leading to anaplastic lymphoma kinase (ALK) overexpression and predicting response to targeted therapy.Expand
Tumor board participation among physicians caring for patients with lung or colorectal cancer.
PURPOSE Multidisciplinary tumor board meetings are common in cancer care, but limited evidence is available about their benefits. We assessed the associations of tumor board participation andExpand
Physicians' attitudes about multiplex tumor genomic testing.
PURPOSE Although predictive multiplex somatic genomic tests hold the potential to transform care by identifying targetable alterations in multiple cancer genes, little is known about how physiciansExpand
Internet use leads cancer patients to be active health care consumers.
OBJECTIVE This study examines whether cancer patients' Internet use leads them to prefer a more active role in medical decision making and whether the effects of Internet use on active participationExpand
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