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Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice.
  • S. Grandy, S. Howlett
  • Medicine, Biology
  • American journal of physiology. Heart and…
  • 1 November 2006
This study characterized age-related alterations in excitation-contraction (EC)-coupling in ventricular myocytes and investigated whether these alterations are affected by the sex of the animal.Expand
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Calcium spark properties in ventricular myocytes are altered in aged mice.
This study determined whether whole cell Ca(2+) transients and unitary sarcoplasmic reticulum (SR) Ca(2+) release events are constant throughout adult life or whether Ca(2+) release is altered inExpand
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Expression, Distribution and Regulation of Sex Steroid Hormone Receptors in Mouse Heart
The effects of sex hormones on the heart are dependent on the presence and distribution of sex steroid hormone receptors (SSHR) in cardiac tissue. This study used subcellular fractionation, WesternExpand
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Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart.
p38 mitogen-activated protein kinases (MAPKs) are serine/threonine specific protein kinases that respond to cellular stress and regulate a broad range of cellular activities. There are four majorExpand
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Cardiovascular disease and physical activity in adult cancer survivors: a nested, retrospective study from the Atlantic PATH cohort
PurposeThe study aimed to examine the relationship between cardiovascular disease (CVD) and physical activity (PA) levels in cancer survivors (CS).MethodsUsing a nested, retrospective follow-upExpand
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Ventricular K+ currents are reduced in mice with elevated levels of serum TNFalpha.
In the present study mice were treated with tumor necrosis factor alpha (TNFalpha) for 6 weeks to determine if chronic TNFalpha treatment could produce serum levels of TNFalpha similar to what hasExpand
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Postnatal development has a marked effect on ventricular repolarization in mice.
To better understand the mechanisms that underlie cardiac repolarization abnormalities in the immature heart, this study characterized and compared K(+) currents in mouse ventricular myocytes fromExpand
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Cardiac repolarization is prolonged in CD4C/HIV transgenic mice.
Pharmacological agents used to treat patients with AIDS have been associated with QT prolongation and result in delayed repolarization. New evidence suggests that delayed repolarization can occurExpand
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Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome
The bacteria that live in our gut have a complex yet vital relationship with our health. Environmental factors that influence the gut microbiome are of great interest, as recent research demonstratesExpand
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A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner
A frailty index (FI) based on clinical deficit accumulation (FI-Clinical) quantifies frailty in aging mice. We aimed to develop a laboratory test-based murine FI tool (FI-Lab) and to investigate theExpand
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