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Cholesterol-lowering activity of various undigested fractions of soybean protein in rats.
The undigested high-molecular-weight fraction (HMF) of soybean protein prepared after exhaustive digestion by microbial proteases significantly decreased serum cholesterol levels to approximately 45%Expand
Age-related changes in lipid metabolism in rats: the consequence of moderate food restriction.
Male Sprague-Dawley rats, 3 weeks of age, received one of the four following dietary manipulations until 9 months of age: group AD, fed ad libitum; group R, restricted to 75% of food intake of groupExpand
Interaction of dietary protein, cholesterol and age on lipid metabolism of the rat.
1. Male rats at 1 (young) and 9 months (adult) of age were fed on purified diets, supplemented with or without cholesterol, containing 200 g protein/kg (casein (CAS), whey protein (WHY) or soya-beanExpand
Steroid-binding peptides from dietary proteins.
  • M. Sugano, S. Goto
  • Chemistry, Medicine
  • Journal of nutritional science and vitaminology
  • 1 October 1990
The undigested high-molecular weight fraction (HMF) of soybean protein prepared after exhaustive digestion either by microbial proteases or by pepsin exerted a remarkable hypocholesterolemic activityExpand
Effect of dietary n−3 polyunsaturated fatty acids on cholesterol synthesis and degradation in rats of different ages
Male Sprague-Dawley rats four weeks or eight months of age were fed purified diets containing 10% fat, either as a blend of safflower oil and palm olein (polyunsaturated fatty acids, PUFA, 34%), aExpand
Hypocholesterolemic effect of the undigested fraction of soy protein.
Cholesterol‐lowering effect of YM‐16638 in cynomolgus monkeys
YM‐16638 was found in preclinical studies to be an orally active leukotriene antagonist. Because LY‐171883, another leukotriene receptor antagonist with a similar structure to YM‐16638, showed aExpand
Species specificity in the blood cholesterol‐lowering effect of YM‐16638
1 . The compound YM‐16638, [[5‐[[3‐(4‐acetyl‐3‐hydroxy‐2‐propylphenoxy)propyl]thio]‐1,3,4‐thiadiazol‐ 2‐yl]thio] acetic acid was developed in a series of in vitro and in vivo studies as a leukotrieneExpand
Hypocholesterolemic effects of the LDL receptor gene transcriptional upregulator CP-230821.
CP-230821 is a novel, potent LDL receptor gene transcriptional upregulator which decreases total plasma cholesterol level. Interestingly, this plasma LDL decrease does not alter hepatic lipidExpand
Effect of YM‐16638, an Orally Active Leukotriene Antagonist, on Alanine Aminotransferase Activity In‐vitro and In‐vivo
YM-16638 ([[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy) propyl]thio]-1,3,4-thiadiazol-2-yl]thio]acetic acid), an orally active leukotriene antagonist, induced a marked decrease in serum alanineExpand