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Molecular Mechanisms of Action of Bisphosphonates: Current Status
Purpose: Bisphosphonates are currently the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia.Expand
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Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature.
Sphingosine-1-phosphate (S1P) regulates various molecular and cellular events in cultured endothelial cells, such as cytoskeletal restructuring, cell-extracellular matrix interactions, andExpand
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Mesenchymal stem cells combined with biphasic calcium phosphate ceramics promote bone regeneration
The reconstruction and repair of large bone defects, resulting from trauma, cancer or metabolic disorders, is a major clinical challenge in orthopaedics. Clinically available biological and syntheticExpand
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Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas/Fas-ligand interactions in experimental autoimmune uveitis.
Conflicting reports have led to the description of nitric oxide as a "double-edged sword" in animal models of autoimmunity. In this study we show that tissue damage within the eye during experimentalExpand
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Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes.
Oxidized analogs of cholesterol (oxysterols) are produced through both enzymatic and non-enzymatic pathways and have been shown to perturb membrane properties in vitro and in vivo. In the presentExpand
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Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma
Summary. Anti‐resorptive bisphosphonates, such as pamidronate, are an effective treatment for osteolytic disease and hypercalcaemia in patients with multiple myeloma, but have also been shown toExpand
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Correlation Among Antifactor Xa, Activated Partial Thromboplastin Time, and Heparin Dose and Association with Pediatric Extracorporeal Membrane Oxygenation Complications
Supplemental Digital Content is available in the text. Anticoagulation is essential during extracorporeal membrane oxygenation (ECMO) to prevent catastrophic circuit clotting. Several assays exist toExpand
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A systematic review of global legal regulations on the permissible level of heavy metals in cosmetics with particular emphasis on skin lightening products
Background: There is an urgent need to address the safety problems caused by the use of skin lightening cosmetics. Evidence suggests that some of them may contain heavy metals. Objectives: WeExpand
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BUN:creatinine ratio - definition of the normal range in children
The normal range for the BUN:Creatinine ratio (BCR) has not been determined for infants and children. The objectives of this study were to: i) test the hypothesis that the BCR is higher in young ch...
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Delirium and ICU