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Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine.
Identification of a central role for complement in osteoarthritis
It is shown that complement, specifically, the membrane attack complex (MAC)-mediated arm of complement, is crucial to the development of arthritis in three different mouse models of osteoarthritis, and dysregulation of complement in synovial joints has a key role in the pathogenesis of arthritis.
Inflammation, fracture and bone repair.
Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro.
It is demonstrated that different levels of IHP differentially modulate hMSC chondrogenesis in the presence of TGF-beta3, suggesting that tissue engineering of articular cartilage through application or recruitment of hMSCs can be facilitated by mechanical stimulation.
Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro.
Adjunctive effects of IHP on TGF-beta 3-induced chondrogenesis are demonstrated and it is suggested that mechanical loading can facilitate articular cartilage tissue engineering.
The future of biologic coatings for orthopaedic implants.
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
- E. Kunkel, James J. Campbell, W. Agace
- Biology, MedicineThe Journal of experimental medicine
- 4 September 2000
Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract.
Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues.
The results suggest that ferumoxytol could be applied 'off label' to protect the liver from metastatic seeds and potentiate macrophage-modulating cancer immunotherapies.
Thromboembolism following multiple trauma.
It appears that there is an identifiable subgroup of injured patients at highest risk for PE who warrant both prophylaxis and close surveillance for DVT, and those with thromboembolic complications were older and spent more hospital days immobilized.
Intraoperative passive kinematics of osteoarthritic knees before and after total knee arthroplasty
- R. Siston, N. Giori, S. Goodman, S. Delp
- MedicineJournal of orthopaedic research : official…
- 1 August 2006
Posterior substituting total knee arthroplasty does not appear to restore normal passive varus/valgus rotations or the screw motion and introduces an abnormal anterior translation of the femur during intraoperative evaluation.