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Identification of a central role for complement in osteoarthritis
Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been viewed as the result of 'wear and tear'. Although low-grade inflammation is detected in… Expand
Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine.
- B. Brown, B. Ratner, S. Goodman, S. Amar, S. Badylak
- Materials Science, Medicine
- 1 May 2012
The host response to biomaterials has been studied for decades. Largely, the interaction of host immune cells, macrophages in particular, with implanted materials has been considered to be a… Expand
Dose- and Time-Dependent Effects of Cyclic Hydrostatic Pressure on Transforming Growth Factor-β3-Induced Chondrogenesis by Adult Human Mesenchymal Stem Cells in Vitro
This study examined effects of varying magnitudes of intermittent hydrostatic pressure (IHP) applied for different times on chondrogenesis of adult human mesenchymal stem cells (hMSCs) in vitro.… Expand
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
- E. Kunkel, J. Campbell, +13 authors W. Agace
- Computer Science, Medicine
- The Journal of experimental medicine
- 4 September 2000
The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial… Expand
Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro.
This study examined the effects of intermittent hydrostatic pressure (IHP) and transforming growth factor-beta 3 on chondrogenesis of adult human mesenchymal stem cells (hMSCs) in vitro. Chondrogenic… Expand
The future of biologic coatings for orthopaedic implants.
Implants are widely used for orthopaedic applications such as fixing fractures, repairing non-unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft tissue… Expand
Inflammation, fracture and bone repair.
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis,… Expand
Complications of ilioischial reconstruction rings in revision total hip arthroplasty.
The complications, management, and outcome of a consecutive series of 61 ilioischial reconstruction rings performed by 1 surgeon over a 15-year period are reported. Structural corticocancellous… Expand
Intraoperative passive kinematics of osteoarthritic knees before and after total knee arthroplasty
- R. Siston, N. Giori, S. Goodman, S. Delp
- Journal of orthopaedic research : official…
- 1 August 2006
Total knee arthroplasty is a successful procedure to treat pain and functional disability due to osteoarthritis. However, precisely how a total knee arthroplasty changes the kinematics of an… Expand
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis.
- R. Paniagua, O. Sharpe, +12 authors W. Robinson
- The Journal of clinical investigation
- 2 October 2006
Tyrosine kinases play a central role in the activation of signal transduction pathways and cellular responses that mediate the pathogenesis of rheumatoid arthritis. Imatinib mesylate (imatinib) is a… Expand