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Identification of a central role for complement in osteoarthritis
Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been viewed as the result of 'wear and tear'. Although low-grade inflammation is detected inExpand
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Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine.
The host response to biomaterials has been studied for decades. Largely, the interaction of host immune cells, macrophages in particular, with implanted materials has been considered to be aExpand
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Dose- and Time-Dependent Effects of Cyclic Hydrostatic Pressure on Transforming Growth Factor-β3-Induced Chondrogenesis by Adult Human Mesenchymal Stem Cells in Vitro
This study examined effects of varying magnitudes of intermittent hydrostatic pressure (IHP) applied for different times on chondrogenesis of adult human mesenchymal stem cells (hMSCs) in vitro.Expand
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Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelialExpand
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Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro.
This study examined the effects of intermittent hydrostatic pressure (IHP) and transforming growth factor-beta 3 on chondrogenesis of adult human mesenchymal stem cells (hMSCs) in vitro. ChondrogenicExpand
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The future of biologic coatings for orthopaedic implants.
Implants are widely used for orthopaedic applications such as fixing fractures, repairing non-unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft tissueExpand
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Inflammation, fracture and bone repair.
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis,Expand
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Complications of ilioischial reconstruction rings in revision total hip arthroplasty.
The complications, management, and outcome of a consecutive series of 61 ilioischial reconstruction rings performed by 1 surgeon over a 15-year period are reported. Structural corticocancellousExpand
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Intraoperative passive kinematics of osteoarthritic knees before and after total knee arthroplasty
Total knee arthroplasty is a successful procedure to treat pain and functional disability due to osteoarthritis. However, precisely how a total knee arthroplasty changes the kinematics of anExpand
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Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis.
Tyrosine kinases play a central role in the activation of signal transduction pathways and cellular responses that mediate the pathogenesis of rheumatoid arthritis. Imatinib mesylate (imatinib) is aExpand
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