• Publications
  • Influence
Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations
Misinterpretation and abuse of statistical tests, confidence intervals, and statistical power have been decried for decades, yet remain rampant. A key problem is that there are no interpretations of
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
Methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of the tumors to alkylating agents and an independent and stronger prognostic factor than age, stage, tumor grade, or performance status.
Circulating mutant DNA to assess tumor dynamics
It is found that ctDNA measurements could be used to reliably monitor tumor dynamics in subjects with cancer who were undergoing surgery or chemotherapy, and it is suggested that this personalized genetic approach could be generally applied to individuals with other types of cancer.
Toward Evidence-Based Medical Statistics. 1: The P Value Fallacy
  • S. Goodman
  • Medicine
    Annals of Internal Medicine
  • 15 June 1999
The historical and logical foundations of the dominant school of medical statistics, sometimes referred to as frequentist statistics, are explored and the logical fallacy at the heart of this system is explicated, which maintains such a tenacious hold on the minds of investigators, policymakers, and journal editors.
Very high risk of cancer in familial Peutz-Jeghers syndrome.
Patients with Peutz-Jeghers syndrome are at very high relative and absolute risk for gastrointestinal and nongastrointestinal cancers.
Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions
The acceptance of a standard classification system will facilitate the study of pancreatic duct lesions, and will lead ultimately to a better understanding of their biologic importance.
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
Patients with advanced colorectal cancers consistently contained mutant adenomatous polyposis coli (APC) DNA molecules in their plasma, which has implications for the mechanisms through which tumor DNA is released into the circulation and for diagnostic tests based on this phenomenon.
Some practical improvements in the continual reassessment method for phase I studies.
Modifications to the Continual Reassessment Method (CRM) are presented, in which one assigns more than one subject at a time to each dose level, and each dose increase is limited to one level, which makes the CRM acceptable to clinical investigators.
Tumor-suppressive pathways in pancreatic carcinoma.
This type of multigenic analysis in human tumors may serve to substantiate experimental tumor models and thus increase the understanding of the truly physiologically relevant tumor-suppressive pathways that are abrogated during human tumorigenesis.
An ethics framework for a learning health care system: a departure from traditional research ethics and clinical ethics.
A new ethics framework is put forward to support the transformation to a learning health care system and to help ensure that learning activities carried out within such a system are conducted in an ethically acceptable fashion.