• Publications
  • Influence
The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling
  • S. Mai, K. Wei, +4 authors S. Gong
  • Biology, Medicine
  • Developmental dynamics : an official publication…
  • 1 June 2010
Missense mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2) have been identified in human craniosynostotic syndromes such as Crouzon (CS) and Pfeiffer (PS). FGFR2 has two major isoforms,Expand
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Identification of Markers of the Midface
Currently, much remains unknown of the genes that mediate the biological events during growth and fusion of the midfacial region, and the possible pathways through which these genes function. We tookExpand
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Bmp4 gene is expressed at the putative site of fusion in the midfacial region.
  • S. Gong, C. Guo
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 1 April 2003
The molecular mechanisms by which the primordia of the midface grow and fuse to form the primary palate portion of the craniofacial region are not well characterized. This is in spite of the factExpand
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The role of Xmsx-2 in the anterior-posterior patterning of the mesoderm in Xenopus laevis.
  • S. Gong, A. Kiba
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 1 November 1999
Many molecules are involved in defining mesodermal patterning of the Xenopus embryo. In this paper, evidence is provided that a member of the msx family of genes, the Xmsx-2 gene, is involved inExpand
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Mouse FLRT2 Interacts with the Extracellular and Intracellular Regions of FGFR2
Fibroblast Growth Factor (FGF) signaling is known to be critical in mediating key developmental events during craniofacial development. Recent evidence suggests that members of the Fibronectin (F)Expand
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FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis
One of the earliest events during chondrogenesis is the formation of condensations, a necessary pre‐requisite for subsequent differentiation of a chondrogenic phenotype. Members of the FibronectinExpand
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The Twirler mouse, a model for the study of cleft lip and palate.
Twirler (Tw) is a semidominant mutation in the mouse affecting the embryonic development of the midfacial region. Most heterozygous Tw mice, +/-, become obese at adulthood with a concomitant decreaseExpand
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Characterization of olfactory nerve abnormalities in Twirler mice.
  • S. Gong
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 1 December 2001
The sense of smell is perceived by olfactory receptor neurons (ORN) present in the olfactory epithelium located in the posterosuperior aspect of the nasal cavity. The axons of these ORN migrate toExpand
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Phenotypic Variation in Dentinogenesis Imperfecta/Dentin Dysplasia Linked to 4q21
Dentinogenesis imperfecta (DGI) and dentin dysplasia (DD) are allelic disorders that primarily affect the formation of tooth dentin. Both conditions are autosomal-dominant and can be caused byExpand
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Palatal development in Twirler mice.
OBJECTIVE The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygousExpand
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