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MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
A mechanism for acquired arrhythmia is revealed: genetically based reduction in potassium currents that remains clinically silent until combined with additional stressors. Expand
Potassium leak channels and the KCNK family of two-p-domain subunits
The discovery of KCNK channels is reviewed, what has been learned about them and what lies ahead: highly regulated, potassium-selective leak channels that function in a most remarkable fashion. Expand
Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*
The genomic structure, cardiac localization, and biophysical properties of a murine example are considered, and single Kcnk3 channels open across the physiological voltage range; hence they are “leak” conductances. Expand
Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium
It is shown that alternative translation initiation (ATI) regulates function of K(2P)2.1 (TREK-1) via an unexpected strategy, which is proposed to be a natural, epigenetic mechanism for spatial and temporal regulation of neuronal excitability. Expand
A common polymorphism associated with antibiotic-induced cardiac arrhythmia.
It is concluded that allelic variants of MiRP1 contribute to a significant fraction of cases of drug-induced LQTS through multiple mechanisms and that common sequence variations that increase the risk of life-threatening drug reactions can be clinically silent before drug exposure. Expand
The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition
Mutagenic scan of the S5-S6 linker sequence of the Shaker K+ channel identified those channel residues influencing CTX binding affinity, and complementary mutagenesis of both CTX and Shaker suggests that Shaker-F425 contacts a specific area near T8 and T9 on the CTX molecular surface. Expand
Forward Transport 14-3-3 Binding Overcomes Retention in Endoplasmic Reticulum by Dibasic Signals
Proteins with dibasic retention motifs are subject to retrograde transport to endoplasmic reticulum (ER) by COPI-coated vesicles. As forward transport requires escape from ER retention, generalExpand
Sumoylation Silences the Plasma Membrane Leak K+ Channel K2P1
Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K+-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage. Expand
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
A novel K+ channel (TOK1) from Saccharomyces cerevisiae that contains two P domains within one continuous poly-peptide that is distinctive in both its primary structure and functional properties is identified. Expand
A minK–HERG complex regulates the cardiac potassium current IKr
It is shown that HERG and minK form a stable complex, and that this heteromultimerization regulates IKr activity, which is central to the control of the heart rate and rhythm. Expand