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Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart
CONTEXT Results from recent studies on the effects of beta1-blockade in patients with heart failure demonstrated a 34% reduction in total mortality. However, the effect of beta1-blockade on theExpand
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Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)
BACKGROUND: Metoprolol can improve haemodynamics in chronic heart failure, but survival benefit has not been proven. We investigated whether metoprolol controlled release/extended release (CR/XL)Expand
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EFFECTS OF A NOVEL TETRAPEPTIDE IN HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF): A PHASE I RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF ELAMIPRETIDE
Elamipretide is a novel tetrapeptide that targets mitochondrial dysfunction and has the potential to augment cardiac function in HFrEF. To assess the safety of elamipretide, 36 subjects with EF ≤Expand
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Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction.
BACKGROUND The Cardiac Arrhythmia Suppression Trial (CAST) tested the hypothesis that the suppression of asymptomatic or mildly symptomatic ventricular premature depolarizations in survivors ofExpand
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The influence of renal function on clinical outcome and response to beta-blockade in systolic heart failure: insights from Metoprolol CR/XL Randomized Intervention Trial in Chronic HF (MERIT-HF).
BACKGROUND Limited information is available on the risk and impact of renal dysfunction on the response to beta-blockade and mode of death in systolic heart failure (HF). METHODS AND RESULTS RenalExpand
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Transplantation of cultured human neuronal cells for patients with stroke
Article abstract Transplantation of cultured neuronal cells is safe in animal models and improves motor and cognitive deficits in rats with stroke. The authors studied the safety and feasibility ofExpand
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Continuous insulin infusion is associated with a reduced post-surgical length of stay, but not with the complication rate, in patients with diabetes mellitus undergoing coronary artery bypass graft
Objective: To establish if glucose management with continuous intravenous insulin infusion (CII) in the early post-operative period after coronary artery bypass graft (CABG) surgery is associatedExpand
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PREVENTION / 3-ADRENERGIC BLOCKADE Effect of propranolol after acute myocardial infarction in patients with congestive heart failure
The incidence of congestive heart failure was studied in the Beta Blocker Heart Attack Trial in which postmyocardial infarction patients between the ages of 30 and 69 years, with no contraindicationExpand