• Publications
  • Influence
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Cerebrospinal fluid flows through channels around brain blood vessels that are bounded by astrocytic endfeet, mediated by water transport through aquaporin-4. A New Footing for Waste Clearance in theExpand
  • 1,996
  • 154
  • PDF
Uniquely Hominid Features of Adult Human Astrocytes
Defining the microanatomic differences between the human brain and that of other mammals is key to understanding its unique computational power. Although much effort has been devoted to comparativeExpand
  • 790
  • 86
  • PDF
New roles for astrocytes: Redefining the functional architecture of the brain
Astrocytes have traditionally been considered ancillary, satellite cells of the nervous system. However, work over the past decade has revealed that they interact with the vasculature to form aExpand
  • 1,208
  • 70
  • PDF
Astrocyte-mediated potentiation of inhibitory synaptic transmission
We investigated the role of astrocytes in activity-dependent modulation of inhibitory synaptic transmission in hippocampal slices. Repetitive firing of an interneuron decreased the probability ofExpand
  • 774
  • 69
P2X7 receptor inhibition improves recovery after spinal cord injury
Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of this phenomenon has largely been unexplored. Here we report that broad regions of the peritraumatic zoneExpand
  • 455
  • 42
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Protoplasmic astrocytes are critically important to energy metabolism in the CNS. Our current understanding of the metabolic interactions between neurons and glia is based on studies using culturedExpand
  • 390
  • 37
  • PDF
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of the congenitally dysmyelinated brain. To establish a potential autologous source of these cells, weExpand
  • 408
  • 33
  • PDF
Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain.
The vocal control nucleus designated HVc (hyperstriatum ventrale, pars caudalis) of adult female canaries expands in response to systemic testosterone administration, which also induces the femalesExpand
  • 932
  • 28
  • PDF
Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
The subcortical white matter of the adult human brain harbors a pool of glial progenitor cells. These cells can be isolated by fluorescence-activated cell sorting (FACS) after either transfectionExpand
  • 459
  • 27
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.
Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous andExpand
  • 421
  • 27
  • PDF