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- Publications
- Influence
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
- Jeffrey J Iliff, Minghuan Wang, +9 authors M. Nedergaard
- Biology, Medicine
- Science Translational Medicine
- 15 August 2012
Cerebrospinal fluid flows through channels around brain blood vessels that are bounded by astrocytic endfeet, mediated by water transport through aquaporin-4. A New Footing for Waste Clearance in the… Expand
Uniquely Hominid Features of Adult Human Astrocytes
- N. A. Oberheim, T. Takano, +10 authors M. Nedergaard
- Biology, Medicine
- The Journal of Neuroscience
- 11 March 2009
Defining the microanatomic differences between the human brain and that of other mammals is key to understanding its unique computational power. Although much effort has been devoted to comparative… Expand
New roles for astrocytes: Redefining the functional architecture of the brain
- M. Nedergaard, B. Ransom, S. Goldman
- Biology, Medicine
- Trends in Neurosciences
- 1 October 2003
Astrocytes have traditionally been considered ancillary, satellite cells of the nervous system. However, work over the past decade has revealed that they interact with the vasculature to form a… Expand
Astrocyte-mediated potentiation of inhibitory synaptic transmission
- J. Kang, L. Jiang, S. Goldman, M. Nedergaard
- Chemistry, Medicine
- Nature Neuroscience
- 1 December 1998
We investigated the role of astrocytes in activity-dependent modulation of inhibitory synaptic transmission in hippocampal slices. Repetitive firing of an interneuron decreased the probability of… Expand
P2X7 receptor inhibition improves recovery after spinal cord injury
- Xiaohai Wang, Gregory Arcuino, +8 authors M. Nedergaard
- Medicine
- Nature Medicine
- 18 July 2004
Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of this phenomenon has largely been unexplored. Here we report that broad regions of the peritraumatic zone… Expand
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
- Ditte Lovatt, U. Sonnewald, +9 authors M. Nedergaard
- Biology, Medicine
- The Journal of Neuroscience
- 7 November 2007
Protoplasmic astrocytes are critically important to energy metabolism in the CNS. Our current understanding of the metabolic interactions between neurons and glia is based on studies using cultured… Expand
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
- Su Wang, J. Bates, +8 authors S. Goldman
- Biology, Medicine
- Cell stem cell
- 7 February 2013
Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of the congenitally dysmyelinated brain. To establish a potential autologous source of these cells, we… Expand
Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain.
- S. Goldman, F. Nottebohm
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1983
The vocal control nucleus designated HVc (hyperstriatum ventrale, pars caudalis) of adult female canaries expands in response to systemic testosterone administration, which also induces the females… Expand
Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
- M. Nunes, N. Roy, +6 authors S. Goldman
- Medicine
- Nature Medicine
- 2003
The subcortical white matter of the adult human brain harbors a pool of glial progenitor cells. These cells can be isolated by fluorescence-activated cell sorting (FACS) after either transfection… Expand
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.
- X. Han, M. Chen, +11 authors M. Nedergaard
- Biology, Medicine
- Cell stem cell
- 7 March 2013
Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and… Expand