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Kappa opioid inhibition of morphine and cocaine self-administration in rats
Two kappa agonists, U50,488 and spiradoline, produced dose-related acute decreases in both morphine and cocaine self-administration in rats; higher doses of both agents were required to decreaseExpand
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Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats
Abstract Rationale. Methamphetamine (METH) and amphetamine (AMPH) are both abused psychostimulants. Although METH is generally accepted to be more addictive and potent than its analogue AMPH, thereExpand
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Effects and aftereffects of ibogaine on morphine self-administration in rats.
Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addition to opiate and stimulant drugs. As a preclinical test of this claim, the present study sought toExpand
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Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum
Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addiction to opioid and stimulant drugs and has been reported to decrease morphine and cocaineExpand
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U50,488, a κ opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats
Because an increase in extracellular levels of dopamine in the nucleus accumbens has been associated with the reinforcing effects of addictive drugs, we investigated whether U50,488, a selectiveExpand
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Rotational movement (circling) in normal humans: sex difference and relationship to hand, foot and eye preference
An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic deviceExpand
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Lateral asymmetry of neurotransmitters in human brain
Data recently published as indicating little or no evidence of neurotransmitter asymmetries in post-mortem human brain were analyzed by correlational and Chi-square procedures. Although handednessExpand
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Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment
18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener that decreases drug self-administration in several animal models, may be a potential treatment for multiple forms of drug abuse. InExpand
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Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization
Repeated cocaine exposure induces locomotor sensitization, which is mediated by adaptive changes in synaptic transmission in the mesolimbic dopamine pathway. The molecular mechanisms underlying thisExpand
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Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies
Assays using radioligands were used to assess the actions of ibogaine and harmaline on various receptor types. Ibogaine congeners showed affinity for opiate receptors whereas harmaline and harmineExpand
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