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Analysis of protein-coding genetic variation in 60,706 humans
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis ofExpand
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.
The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has becomeExpand
Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis.
It has been reported that post-natal day (PD) 30-40 rats respond differently to the behavioral effects of dopaminergic drugs when compared to younger or older rats. In this study, the behavioralExpand
Meta‐analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders
Family, twin, and adoption studies show that psychiatric diseases including bipolar disorder (BP) and unipolar disorder (UP) have a substantial genetic component. For these illnesses, both positiveExpand
A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes.
OBJECTIVES Medications used to treat attention-deficit/hyperactivity disorder (ADHD) in adults have been well researched, but comparisons among drugs are hindered by the absence of direct comparativeExpand
Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.
OBJECTIVE There is strong evidence for a genetic contribution to schizophrenia, but efforts to identify susceptibility genes have been largely unsuccessful because of the low power of individualExpand
Psychopharmacology and aggression. I: A meta-analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD.
OBJECTIVE To determine by meta-analysis the effect size for stimulants on overt and covert aggression-related behaviors in children with attention-deficit/hyperactivity disorder (ADHD), separatelyExpand
Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.
Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of 1 variantExpand
Meta‐analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity
There is strong evidence for a genetic contribution to the pathogenesis of panic disorder, with the functional catechol‐O‐methyltransferase (COMT) val158met polymorphism having been suggested as aExpand
Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: A preliminary report
DNA methylation changes could provide a mechanism for DNA plasticity and dynamism for short‐term adaptation, enabling a type of cell memory to register cellular history under different environmentalExpand