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Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
Genealogy can illuminate the evolutionary path of important human pathogens. In some microbes, strict clonal reproduction predominates, as with the worldwide dissemination of Mycobacterium leprae,Expand
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Transcriptional Network of Multiple Capsule and Melanin Genes Governed by the Cryptococcus neoformans Cyclic AMP Cascade
ABSTRACT Cryptococcus neoformans is an opportunistic human fungal pathogen that elaborates several virulence attributes, including a polysaccharide capsule and melanin pigments. A conserved GαExpand
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The Cryptococcus neoformans Catalase Gene Family and Its Role in Antioxidant Defense
ABSTRACT In the present study, we sought to elucidate the contribution of the Cryptococcus neoformans catalase gene family to antioxidant defense. We employed bioinformatics techniques to identifyExpand
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Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have beenExpand
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Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host.
The temporal synthesis of the P21 protein of Borrelia burgdorferi and the development of the humoral response to this antigen was assessed in infected mice. p21 is a member of the ospE-F gene familyExpand
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Identification of Cryptococcus neoformans Temperature-Regulated Genes with a Genomic-DNA Microarray
ABSTRACT The ability to survive and proliferate at 37°C is an essential virulence attribute of pathogenic microorganisms. A partial-genome microarray was used to profile gene expression in theExpand
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Cryptococcus neoformans α Strains Preferentially Disseminate to the Central Nervous System during Coinfection
ABSTRACT Cryptococcus neoformans is a fungal pathogen that has evolved over the past 40 million years into three distinct varieties or sibling species (gattii, grubii, and neoformans). Each varietyExpand
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Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.
Cryptococcus neoformans is an opportunistic pathogen and the leading cause of fungal meningitis. To survive within the host, this organism must be able to protect itself from oxidative stress.Expand
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Adenylyl Cyclase-Associated Protein Aca1 Regulates Virulence and Differentiation of Cryptococcus neoformans via the Cyclic AMP-Protein Kinase A Cascade
ABSTRACT The evolutionarily conserved cyclic AMP (cAMP) signaling pathway controls cell functions in response to environmental cues in organisms as diverse as yeast and mammals. In theExpand
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Peroxisome Function Regulates Growth on Glucose in the Basidiomycete Fungus Cryptococcus neoformans
ABSTRACT The function of the peroxisomes was examined in the pathogenic basidiomycete Cryptococcus neoformans. Recent studies reveal the glyoxylate pathway is required for virulence of diverseExpand
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