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A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis
Epithelial ovarian cancer is the most lethal gynecologic malignancy; it is highly aggressive and causes almost 125,000 deaths yearly. Despite advances in detection and cytotoxic therapies, a lowExpand
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MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway
MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription‐independent mitochondrial functions. MDM4 binds to p53 and blocks itsExpand
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MicroRNA miR‐24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a
Cell cycle progression is controlled by numerous mechanisms ensuring correct cell division. The transition from one cell cycle phase to another occurs in an orderly fashion and is regulated byExpand
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MDM4 (MDMX) Overexpression Enhances Stabilization of Stress-induced p53 and Promotes Apoptosis*
Rescue of embryonic lethality in MDM4-/- mice through concomitant loss of p53 has revealed a functional partnership between the two proteins. Biochemical studies have suggested that MDM4 may act as aExpand
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Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.
The HDMX protein is closely related to HDM2 with which it shares different structural domains, particularly the p53 binding domain and the ring finger domain, where the two HDM proteins interact.Expand
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Using social media to identify tourism attractiveness in six Italian cities
Abstract The technological revolution and the widespread of social media have allowed people to generate tremendous amounts of data every day. Social networks provide users with access toExpand
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Papillary carcinoma of the thyroid: high expression of COX-2 and low expression of KAI-1/CD82 are associated with increased tumor invasiveness.
BACKGROUND We have previously demonstrated that expression of COX-2 is upregulated by hepatocyte growth factor in thyroid papillary carcinoma (TPC) cells and is associated with increased invasivenessExpand
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Regulation of MDM4 (MDMX) function by p76MDM2: a new facet in the control of p53 activity
Under basal growth conditions, p53 function is tightly controlled by the members of MDM family, MDM2 and MDM4. The Mdm2 gene codes, in addition to the full-length p90MDM2, for a short protein,Expand
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Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
A wild-type (wt) p53 gene characterizes thyroid tumors, except for the rare anaplastic histotype. Because p53 inactivation is a prerequisite for tumor development, alterations of p53 regulatorsExpand
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Role of microRNAs in the molecular diagnosis of cancer
MicroRNAs (miRNAs) are evolutionarily conserved, endogenous, small non-coding RNA molecules of about 22 nucleotides in length that function as posttranscriptional gene regulators. They are involvedExpand
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