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Dendritic cells: biology of the skin
Allergic contact dermatitis results from a T‐cell‐mediated, delayed‐type hypersensitivity immune response induced by allergens. Skin dendritic cells (DCs) play a central role in the initiation ofExpand
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CXCL8 secretion by dendritic cells predicts contact allergens from irritants.
Monocyte-derived dendritic cell functions have been explored for identification of contact allergens in vitro. Current methods, including measurement of changes in cell surface marker expressionExpand
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CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis
The initial step in Langerhans cell (LC) migration from the epidermis to the lymph node involves migration of maturing LC into the dermis. Here, we investigated the migration of LC out of theExpand
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Wound‐healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes
Full‐skin substitutes, epidermal substitutes, and dermal substitutes are currently being used to heal deep burns and chronic ulcers. In this study, we investigated which wound‐healing mediators areExpand
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Structure‐activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000‐fold
Wounds in the mouth heal faster and with less scarification and inflammation than those in the skin. Saliva is thought to be essential for the superior oral wound healing, but the involved mechanismExpand
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Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells
Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming hypertrophic scars. Differences in woundExpand
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The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins.
Loricrin, involucrin, small proline-rich protein (SPRR)1, SPRR2, and SPRR3 genes are located within a cluster of 1.5 Mbp on chromosome 1q21 and most likely evolved from a common ancestor.Expand
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Characterization of Reconstructed Skin Models
The aim of the present study was to evaluate tissue architecture and lipid composition of commercially available reconstructed human skin models; EpiDerm™, SkinEthic™ and Episkin™ in comparison toExpand
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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.
The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. Expand
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Transcriptional profiling of human skin‐resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions
In human skin, two main populations of dendritic cells (DC) can be discriminated: dermal DC (DDC) and epidermal Langerhans cells (LC). Although extensively studied, most of the knowledge about DDCExpand
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