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Monoclonal Antibodies: A Tool in Clinical Research
Monoclonal antibodies (MAbs) are an old immunological tool with applications in the fields of immunology, biotechnology, biochemistry, and applied biology. Production of monoclonal antibodies usingExpand
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O-acetylation of sialic acids is required for the survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL)
Exploiting the selective affinity of Achatinin-H towards 9-O-acetylneuraminic acid(α2-6)GalNAc, we have demonstrated the presence of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs) on hematopoieticExpand
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Fractured migrated oesophageal stent fragment presenting as small bowel obstruction three years after insertion.
Oesophageal stent migration is a recognised complication; however, few present distal to the stomach causing obstruction. To date, this has never been reported as occurring later than 2 years afterExpand
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Altered erythrocyte membrane characteristics during anemia in childhood acute lymphoblastic leukemia
Anemia is a prominent feature in children with acute lymphoblastic leukemia (ALL). To investigate the erythrocyte features during anemia in these patients, we studied the altered characters of theseExpand
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Differential expression of 9‐O‐acetylated sialoglycoconjugates on leukemic blasts: A potential tool for long‐term monitoring of children with acute lymphoblastic leukemia
Earlier studies have demonstrated overexpression of 9‐O‐acetylated sialoglycoconjugates (9‐O‐AcSGs) on lymphoblasts, concomitant with high titers of anti‐9‐O‐AcSG antibodies in childhood acuteExpand
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Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukemia.
Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Exploiting the selective affinity of Achatinin-H towardExpand
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Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease‐specific 9‐O‐acetylated sialoglycoconjugates in children suffering from
Disease‐specific over‐expression of 9‐O‐acetylated sialoglycoconjugates (9‐O‐AcSGs) on peripheral blood mononuclear cells (PBMC) of children with acute lymphoblastic leukaemia (ALL, PBMCALL) has beenExpand
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Interferon gamma promotes survival of lymphoblasts overexpressing 9‐O‐acetylated sialoglycoconjugates in childhood acute lymphoblastic leukaemia (ALL)
An enhanced linkage‐specific 9‐O‐acetylated sialic acid (9‐O‐AcSA) on peripheral blood mononuclear cells (PBMC) of children with acute lymphoblastic leukaemia, ALL (PBMCALL, 9‐O‐AcSA+ cells) wasExpand
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Sialic acids: biomarkers in endocrinal cancers
  • S. Ghosh
  • Biology, Medicine
  • Glycoconjugate Journal
  • 17 March 2015
Sialylations are post translational modification of proteins and lipids that play important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations dueExpand
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Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods
Abstract. Death through apoptosis is the main process by which aged cells that have lost their function are eliminated. Apoptotic cells are usually detected microscopically by changes in theirExpand
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