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Prion proteins and the gut: une liaison dangereuse?
Ever since Gajdusek implicated a “slow virus” in the transmission of Kuru, the oral route of “infection” of spongiform encephalopathies has attracted considerable interest and Prusiner's hypothesis that TSEs are caused by small proteinaceous infectious particles “prions” took considerable time to gain widespread recognition among the scientific establishment. Expand
Baculovirus‐expressed vitamin D‐binding protein‐macrophage activating factor (DBP‐maf) activates osteoclasts and binding of 25‐hydroxyvitamin D3 does not influence this activity
Osteoclast activity was determined by evaluating pit formation using osteoclasts, isolated from the long bones of newborn rats, incubated on calcium phosphate coated, thin film, Ostologic MultiTest Slides, and data support the essential role of glycosylation for the osteoclast activating property of DBP‐maf. Expand
Diverse patterns of expression of the 67‐kD laminin receptor in human small intestinal mucosa: potential binding sites for prion proteins?
It has been shown that the 67‐kD laminin receptor (LR) may function as a receptor for Sindbis and tick‐born encephalitis viruses. Recent data indicate that the 37‐kD precursor (LRP) for this moleculeExpand
Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. A double-blind placebo-controlled trial.
It is concluded that DDAVP shortens BT in majority of CPD patients with normal dense granule stores and suggest that BT response may be dependent on the underlying platelet defect. Expand
Bacterial expression of human vitamin D-binding protein (Gc2) in functional form.
In this report, we report the first expression of human vitamin D-binding protein (hDBP), a serum protein with several functions and a multidomained structure, in Escherichia coli. The recombinantExpand
Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes
It is demonstrated and signifies that changes occur in the expression of CS proteins in HCV‐infected hepatocytes and, for the first time, shows the up‐regulation and interaction of fila with HCV proteins. Expand
Levuglandin E2 crosslinks proteins.
Levuglandin E2 (LGE2), a gamma-ketoaldehyde produced by rearrangement of the prostaglandin endoperoxide PGH2 under the aqueous conditions of its biosynthesis, causes extensive intermolecularExpand
Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins.
Levuglandin E2 (LGE2), a gamma-ketoaldehyde produced by rearrangement of the prostaglandin endoperoxide PGH2 under the aqueous conditions of its biosynthesis, binds covalently with ram seminalExpand
Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface
The present data suggest that although FVIIa variants generate substantial amounts of FXa, they do not generate excessive thrombin on the surface of endothelium. Expand
Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective
These patients have a unique inherited platelet defect in formation of two key intracellular mediators [I(1,4,5)P3 and DG] and in the responses mediated by them due to a defect in postreceptor mechanisms of PLC activation. Expand