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Signaling to NF-kappaB.
An overview of established NF-kappaB signaling pathways is provided with focus on the current state of research into the mechanisms that regulate IKK activation and NF- kappaB transcriptional activity.
Shared Principles in NF-κB Signaling
Missing Pieces in the NF-κB Puzzle
NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Despite the tremendous progress that has been made in understanding the regulation of NF-κB, there is much that remains to be understood and the fundamental questions that remain unanswered after 25 years of study are highlighted.
The NF-kappaB family of transcription factors and its regulation.
- Andrea Oeckinghaus, S. Ghosh
- Biology, Computer ScienceCold Spring Harbor perspectives in biology
- 1 October 2009
The NF-kappaB pathway is a paradigm for understanding general principles of signal transduction and gene regulation as well as other pathway-specific mediators, and the transcription factors are themselves extensively modified.
Mitochondria in innate immune responses
This work reviews the emerging knowledge about the roles of mitochondria in innate immunity and suggests mitochondria appear to function as centrally positioned hubs in the innate immune system.
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.
Crosstalk in NF-κB signaling pathways
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied…
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
The studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways.
Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip*
It is reported that Tollip also associates directly with TLR2 and TLR4 and plays an inhibitory role in TLR-mediated cell activation and is phosphorylated by IRAK upon stimulation with lipopolysaccharide or IL-1.