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Guidelines for the use and interpretation of assays for monitoring autophagy
TLDR
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase‐dependent pathway
TLDR
The data indicate that S100A8/A9‐promoted cell growth occurs through RAGE signaling and activation of NF‐κB, which is mediated via RAGE ligation.
High Prevalence of Vitamin D Deficiency in Zahedan, Southeast Iran
TLDR
It is indicated that vitamin D deficiency is common in the population of Zahedan, a sunny area in southeast Iran and fortification of milk and the use of supplements is suggested in this region.
Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a
TLDR
The data indicate that the apoptin death signal(s) ultimately converges at the mitochondria, and that it acts independently of the death receptor pathway.
Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis.
TLDR
It is demonstrated that the hsa-mir-499 rs3746444, but not mir-146a rs2910164, polymorphism is associated with an increased RA risk in a sample of the Iranian population.
Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway
TLDR
Results show that Brevinin‐2R activates the lysosomalmitochondrial death pathway, and involves autophagy‐like cell death, as well as interacts with both early and late endosomes.
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