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Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety.
Risperidone plus a mood stabilizer was more efficacious than a mood stabilizeizer alone, and as efficacious as haloperidol plus a Mood stabilizer, for the rapid control of manic symptoms and was well tolerated. Expand
“Cade's Disease” and Beyond: Misdiagnosis, Antidepressant Use, and a Proposed Definition for Bipolar Spectrum Disorder
A critical review of studies concerning the nosology of bipolar disorder and the effects of antidepressant agents leads to the conclusion that there should be less emphasis on using antidepressants to treat sons with this illness. Expand
Is bipolar disorder still underdiagnosed? Are antidepressants overutilized?
Systematic application of DSM-IV criteria identified previously undiagnosed bipolar disorder in 40% of a referred population of patients with mood disorders, all previously misdiagnosed as unipolar major depressive disorder. Expand
Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study.
It is suggested that bipolar disorder tends be misdiagnosed as unipolar major depressive disorder and that antidepressants seem to be associated with a worsened course of bipolar illness. Expand
Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder.
The MDQ demonstrates good sensitivity in insightful patients with bipolar I disorder, but may be less useful in patients with impaired insight or milder bipolar spectrum conditions, as compared to DSM-IV-based SCID diagnoses. Expand
The rise and fall of the biopsychosocial model
  • S. Ghaemi
  • Psychology, Medicine
  • British Journal of Psychiatry
  • 1 July 2009
Summary The biopsychosocial model is the conceptual status quo of contemporary psychiatry. Although it has played an important role in combatting psychiatric dogmatism, it has devolved into mereExpand
Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD.
A history of psychosis, age at onset, bipolar I versus II subtype, history of rapid cycling, prior hospitalizations, current illness state, and history of alcohol or substance use disorders did not significantly alter the risk profiles for receiving complex regimens. Expand
A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder.
  • A. Wingo, S. Ghaemi
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 15 November 2007
The diagnostic validity of adult ADHD/ bipolar disorder as a true comorbidity is not well-established on the basis of this equivocal and insufficient literature, and more studies are greatly needed to further clarify its diagnostic validity and treatment approach. Expand
Diagnostic validity of comorbid bipolar disorder and obsessive–compulsive disorder: a systematic review
Defining the nosology of BD‐OCD comorbidity has important clinical implications, given that treatments for OCD can worsen BD outcomes. Expand