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Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer.
It is indicated that a complex interaction between host factors such as oxidative stress, antioxidant capacity and efficiency of multiple DNA repair pathways underlies the inter-individual variability in GC risk. Expand
Individual susceptibility and alcohol effects:biochemical and genetic aspects.
The large interethnic and interindividual variability in alcohol-induced toxic effects comes from a combination of genetic and environmental factors, influencing ethanol toxicokinetics. The hepatic… Expand
Interleukin-1 Gene Polymorphisms and Gastric Cancer Risk in a High-Risk Italian Population
- D. Palli, C. Saieva, +17 authors M. Gomez-Miguel
- Medicine, Biology
- The American Journal of Gastroenterology
- 1 September 2005
The results suggest that host genetic factors interaction in the complex process of gastric carcinogenesis in this high-risk Italian population appears more modest than previously reported in other populations, supporting the hypothesis that other still-to-be-defined factors are important in gastrics carcinogenesis. Expand
Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene-environment interaction.
The GSTs polymorphisms per se do not increase the risk of developing endometriosis, but a gene-environment interaction was observed for GSTP1(Ile/Ile) and GSTM1 null genotypes, modulating the effect of PCB153, PCB180, and of total PCBs on disease risk. Expand
Metabolism of chloroform in the human liver and identification of the competent P450s.
- S. Gemma, L. Vittozzi, E. Testai
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 March 2003
The role of human CYP2E1 in CHCl(3) metabolism at low levels, typical of actual human exposure, provides insight into the molecular basis for eventual difference in susceptibility to chloroform-induced effects due to either genetic, pathophysiological, or environmental factors. Expand
Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome
One of the major factors determining the peak blood alcohol exposure to the fetus is the metabolic activity of the mother, in addition to placental and fetal metabolism, explaining, at least partially, the risk of FAS. Expand
Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver
- L. Fabrizi, S. Gemma, E. Testai, L. Vittozzi
- Chemistry, Medicine
- Journal of biochemical and molecular toxicology
The metabolism of diazinon, an organophosphorothionate pesticide, to diazoxon and pyrimidinol has been studied in incubations with hepatic microsomes from control Sprague–Dawley (SD) rats or SD rats… Expand
GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population
- D. Palli, C. Saieva, +12 authors E. Testai
- Biology, Medicine
- International journal of cancer
- 1 June 2005
It is suggested that only subjects lacking both GSTM1 and GSTT1 activity are at increased GC risk, providing further support to the hypothesis that the risk of developing GC is influenced by inter‐individual variation in both carcinogen detoxification and antioxidant capacity. Expand
Biomonitoring of perfluorinated compounds in adults exposed to contaminated drinking water in the Veneto Region, Italy.
The contamination of drinking water of the residence area was found to be the main factor influencing PFAS serum levels; in addition to water contamination, other relevant influencing factors were sex, the years of residence and raising own livestock. Expand
In vivo CHCl3 bioactivation, toxicokinetics, toxicity, and induced compensatory cell proliferation in B6C3F1 male mice.
- S. Gemma, S. Faccioli, P. Chieco, M. Sbraccia, E. Testai, L. Vittozzi
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 December 1996
Observations raise questions about the purely epigenetic action of chloroform in tumor induction since bioassays have found tumors in liver but not kidneys of CHCl3-treated B6C3F1 mice. Expand