• Publications
  • Influence
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
The cleavage by OMA1 causes an accumulation of the short OPA1 variants, and the role ofm-AAA proteases in ensuring a balance of long and short Opa1 isoforms is investigated. Expand
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.
Conditional gene targeting of murine Phb2 is used to define cellular activities of prohibitins and assign an essential function for the formation of mitochondrial cristae to prohibitingins and suggest a coupling of cell proliferation to mitochondrial morphogenesis. Expand
The ultrastructure of the Chlamydomonas reinhardtii basal apparatus: identification of an early marker of radial asymmetry inherent in the basal body
The early harbinger of radial asymmetry described here could play a crucial role during basal body maturation by orienting the asymmetric attachment of the various associated fibers and therefore might define the orientation of the basal bodies and, ultimately, the direction of flagellar beating. Expand
The Arabidopsis Plastidic Glucose 6-Phosphate/Phosphate Translocator GPT1 Is Essential for Pollen Maturation and Embryo Sac Development
The results indicate that GPT1-mediated import of glucose 6-phosphate into nongreen plastids is crucial for gametophyte development, and suggests that loss of G PT1 function results in disruption of the oxidative pentose phosphate cycle, which in turn affects fatty acid biosynthesis. Expand
Dissecting the Molecular Mechanisms of Intraflagellar Transport in Chlamydomonas
A model for IFT in which tip turnaround involves dissociation of IFT complexes A and B and release of inactive cDynein1b from complex B is supported and the IFT tip turnaround point most likely is localized distal to the plus end of the outer-doublet B MTs. Expand
Chlamydomonas IFT172 Is Encoded by FLA11, Interacts with CrEB1, and Regulates IFT at the Flagellar Tip
The results indicate that IFT172 is involved in regulating the transition between anterograde and retrograde IFT at the tip, perhaps by a mechanism involving CrEB1. Expand
Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control.
POC1, a highly abundant WD40 domain-containing centriole protein, is characterized, finding that POC1 is recruited to nascent procentrioles and localizes in a highly asymmetrical pattern in mature centrioles corresponding to sites of basal-body fiber attachment, suggesting that Poc1 is involved in early steps ofCentriole duplication as well as in the later steps of Centriole length control. Expand
Electron-tomographic analysis of intraflagellar transport particle trains in situ
Ultrastructural study of Chlamydomonas cilia shows that anterograde IFT particles form trains that are long and narrow, while retrograde IFT form short, compact particle trains.
Chlamydomonas IFT70/CrDYF-1 Is a Core Component of IFT Particle Complex B and Is Required for Flagellar Assembly
The results demonstrate that DYF-1 is a canonical subunit of IFT particle complex B and strongly support the hypothesis that the IFT machinery has species- and tissue-specific variations with functional ramifications. Expand
Centrin Scaffold in Chlamydomonas reinhardtii Revealed by Immunoelectron Microscopy
A role for a rotationally asymmetric centrin “seed” in the growth and development of the centrin scaffold following replication of the basal apparatus is suggested. Expand