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Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant
TLDR
The aim of this work was to determine whether immunization with a non-toxic variant of NetB and the C-terminal fragment of C. perfringens alpha-toxin would provide protection against experimental necrotic enteritis. Expand
A Salmonella Enteritidis hilAssrAfliG deletion mutant is a safe live vaccine strain that confers protection against colonization by Salmonella Enteritidis in broilers.
TLDR
This is the first report of an attenuated Salmonella strain for which both the safety and efficacy has been shown in long-term experiments (until slaughter age) in broiler strain can potentially be used as a live colonization-inhibition strain for controllingSalmonella Enteritidis infections in broilers. Expand
Bacillus amyloliquefaciens as prophylactic treatment for Clostridium difficile‐associated disease in a mouse model
TLDR
A Bacillus amyloliquefaciens strain was selected for its high in vitro antibacterial activity against C. difficile and its efficacy to prevent CDI in a mouse model was tested. Expand
Vegetative Bacillus amyloliquefaciens cells do not confer protection against necrotic enteritis in broilers despite high antibacterial activity of its supernatant against Clostridium perfringens in
TLDR
It is demonstrated that despite its substantial inhibitory activity in vitro, lyophilised vegetative B. amyloliquefaciens cells had no beneficial effect against necrotic enteritis in the in vivo model used here. Expand
Perfrin, a novel bacteriocin from a necrotic enteritis associated Clostridium perfringens strain
TLDR
Amino acid sequence analysis indicated that the bacteriocin is a 11.5 kDa fragment of a 22.91 kDa protein and that it constitutes the C-terminal part of this protein and the antibacterial activity of the purified bacteriOCin was abolished by proteolytic enzymes trypsin and proteinase K and by heat treatment. Expand
Bacillus amyloliquefaciens does not confer protection against necrotic enteritis in an in vivo broiler model despite high in vitro antibacterial activity
TLDR
It is demonstrated that despite its substantial inhibitory activity in vitro, B. amyloliquefaciens had no beneficial effect against necrotic enteritis in the in vivo model used here. Expand
Use of Bacillus amyloliquefaciens for Clostridium perfringens and Clostridium difficile associated disease
TLDR
The results indicate that B. amyloliquefaciens SG1 produces at least one compound, the lipopeptide surfactin, with potent antibacterial activity towards C. difficile, making the strain or the lipOPEptide a potential alternative treatment option for C. Difficile associated disease. Expand
Use of Bacillus amyloliquefaciens for the prophylactic treatment of Clostridium difficile infections
TLDR
Results of the in vivo trial clearly indicate a positive effect of administration of B. amyoliquefaciens to prevent CDI, which might help to control the increasing incidences in morbidity and mortality due to this disease. Expand