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Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain
Results suggest a functional specialization of OCT subtypes, based both on their intrinsic properties and their differential regional expression pattern in the brain, which is also found to be sensitive to 3,4-methylenedioxymetamphetamine, phencyclidine, MK-801 and ketamine. Expand
Organic Cation Transporter 3 (Slc22a3) Is Implicated in Salt-Intake Regulation
It is demonstrated that the presence of OCT3 is critical for the balanced neural and behavioral responses to environmentally induced variations in osmolarity and provides for the first time physiological evidence of the importance of OCTs for CNS function. Expand
Transcription of the dystrophin gene in human muscle and non-muscle tissues
It is reported here that efficient in vitro co-amplifications of the mRNAs of the dystrophin gene and of a reporter gene, aldolase A, by the poly-merase chain reaction procedure enables us to obtain a quantitative estimate of the DystrophIn gene transcript. Expand
The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression.
The isolation and characterization of a cDNA encoding the C-terminal portion of a putative glial Na-channel (Na-G) alpha subunit indicates that the Na-G represents a separate molecular class within the mammalian Na- channel multigene family. Expand
Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response
It is reported that OCT2, a member of the polyspecific organic cation transporter (OCT) family, is expressed notably in the limbic system and implicated in anxiety and depression-related behaviors in the mouse. Expand
Altered aminergic neurotransmission in the brain of organic cation transporter 3‐deficient mice
A role of OCT3 in the homeostastic regulation of aminergic neurotransmission in the brain is supported by a detailed immunohistochemistry study that shows that OCT3 is expressed in am inergic pathways in the mouse brain. Expand
Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism
Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by marked genetic heterogeneity. Recent studies of rare structural and sequence variants have identified hundredsExpand
Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3
Under the assumption of a tenfold accumulation in the brain, bupropion, nefazodone and clozapine may notably inhibit the corresponding hOCTs and it remains to be shown whether such a direct inhibition plays a role in the clinical effects of these three drugs. Expand
Role of organic cation transporters (OCTs) in the brain.
Substantiated evidence indicate that OCTs may serve in the brain as a compensatory clearance system in case of monoamine spillover after high-affinity transporter blockade by antidepressants or psychostimulants, and in areas of lower high-Affinity transporter density at distance from the aminergic varicosities. Expand
Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling
It is reported that OCT2 is expressed in several stress-related circuits in the brain and along the hypothalamic-pituitary-adrenocortical (HPA) axis and suggested that in humans OCT2 mutations or blockade by certain therapeutic drugs could interfere with HPA axis function and enhance vulnerability to repeated adverse events leading to stress- related disorders. Expand