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Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: The Seniors Health and Activity Research Program Pilot (SHARP-P)
TLDR
Good levels of participation, adherence, and retention appear to be achievable for participants through age 85 years, and depending on the choice of outcome measures, the necessary sample sizes to conduct four-year trials appears to be feasible.
Postmenopausal hormone therapy and cognitive outcomes: The Women's Health Initiative Memory Study (WHIMS)
Impact of Intensive Lifestyle Intervention on Depression and Health-Related Quality of Life in Type 2 Diabetes: The Look AHEAD Trial
TLDR
ILI for overweight/obese patients with type 2 diabetes may reduce the risk of developing clinically significant symptoms of depression and preserve physical HRQoL.
Risk factors for endometrial cancer in black and white women: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)
TLDR
The major known risk factors for EC exert similar effects on black and white women, and Differences in the incidence rates between the two populations may be due to differences in the prevalence of risk factors.
Cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes
TLDR
Among Look AHEAD participants, depression symptoms or ADM use on entry to the study were each independently associated with a wide range of CVD risk factors.
Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
TLDR
Among ambulatory adults with hypertension, treating to a systolic blood pressure goal of less than 120 mm Hg compared with a goal of more than 140mm Hg did not result in a significant reduction in the risk of probable dementia.
Cognitive Function and Kidney Disease: Baseline Data From the Systolic Blood Pressure Intervention Trial (SPRINT).
TLDR
In older adults, higher urine ACR and lower eGFR have independent associations with global cognitive performance with different affected domains, suggesting that vascular disease may mediate these relationships.
Four-Year Change in Cardiorespiratory Fitness and Influence on Glycemic Control in Adults With Type 2 Diabetes in a Randomized Trial
TLDR
A 4-year ILI increased fitness and PA in overweight/obese individuals with T2DM and was associated with improvements in glycemic control, which provides support for interventions to improve fitness in adults with T1DM.
Weight Change and Cognitive Function: Findings From the Women's Health Initiative Study of Cognitive Aging
TLDR
There was a lack of associations between weight and cognition in women who remained stable or gained weight, and the only significant relationships observed were in association with weight loss (P ≤ 0.05), most likely signaling incipient disease.
Intraindividual Variability in Domain-Specific Cognition and Risk of Mild Cognitive Impairment and Dementia
TLDR
It is demonstrated that within-person variability across cognitive domains both at baseline and longitudinally independently accounts for risk of cognitive impairment and dementia in support of the predictive utility of within- person variability.
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