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A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells
To better elucidate the molecular mechanism of repression by E2F-6, the factor is purified from cultured cells and chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1γ, and Polycomb group (PcG) proteins are suggested to contribute to silencing of E1- and Myc-responsive genes in quiescent cells. Expand
The subcellular localization of E2F-4 is cell-cycle dependent.
The subcellular location of E2F-4 is regulated in a cell cycle-dependent manner, providing another potential mechanism for its functional regulation. Expand
LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G2/M Genes
Here we report the identification of the LIN complex (LINC), a human multiprotein complex that is required for transcriptional activation of G2/sub>/M genes. LINC is related to the recentlyExpand
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.
It is reported that simultaneous inactivation of E 2F4 and E2F5 in mice results in neonatal lethality, suggesting that they perform overlapping functions during mouse development. Expand
Transcriptional activation by Myc is under negative control by the transcription factor AP‐2.
AP‐2 acts as a negative regulator of transactivation by Myc, and high affinity binding sites for AP‐2 overlap Myc‐response elements in two bona fide target genes of Myc. Expand
An intact retinoblastoma protein‐binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells
In a xeno‐transplantation model, it is proved that TA expression is essential also in an in vivo situation, as knock down of TA leads to tumor regression, and interference with LTA/RB interaction appears as promising strategy to treat MCC. Expand
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription.
E2F6 functions as a repressor of E2F-dependent transcription during S phase and given the specificity for the G1/S-regulated genes, it is proposed that E2f6 functions to distinguish G 1/S and G2/M transcription during the cell cycle. Expand
LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence‐specific manner
The data demonstrate that LIN54 is an important and integral subunit of LINC, and two binding sites for LIN54 in the cdc2 promoter overlaps with the cell cycle homology region at the transcriptional start site. Expand
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.
Cl cloning and characterization of E2F-6 suggest that E2f-6 can regulate a subset of E1F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Expand
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting.
Although embryonic development appeared normal, newborn mice developed nonobstructive hydrocephalus, suggesting excessive cerebrospinal fluid (CSF) production, E2F-5 is not essential for cell proliferation, rather, it affects the secretory behavior of a differentiated neural tissue. Expand