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Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients
TLDR
In vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication. Expand
Overview on plant antimicrobial peptides.
TLDR
This review focuses on a special category of defense molecules, the plant antimicrobial peptides, providing an overview of their main molecular features and structures. Expand
Anti-inflammatory and antinociceptive activities of indole-imidazolidine derivatives.
TLDR
Evaluated hybrid molecules containing imidazole and indole nuclei exhibited promising anti-inflammatory and antinociceptive activities that likely involved the modulation of the immune system. Expand
The evolution of drugs on schistosoma treatment: looking to the past to improve the future.
TLDR
A panorama of drugs that were and are being used in human chemotherapy looking to the past to improve rational design drugs in the future is provided. Expand
Enhanced Antiproliferative Activity of the New Anticancer Candidate LPSF/AC04 in Cyclodextrin Inclusion Complexes Encapsulated into Liposomes
TLDR
It is verified that HP-β-CyD complexation enhances the aqueous solubility of L PSF/AC04, and a significant increase in the antiproliferative activity of LPSF/ AC04 against cell lines can be achieved by the encapsulation into liposomes. Expand
GQ-16, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Promotes Insulin Sensitization without Weight Gain
TLDR
The results suggest that the emerging model, whereby “ideal” PPARγ-based therapeutics stabilize the β-sheet/Ser-273 region and inhibit Cdk5-mediated phosphorylation while minimally invoking adipogenesis and classical agonism, is indeed a valid framework to develop improved PParγ modulators that retain antidiabetic actions while minimizing untoward effects. Expand
Interaction of morphine with a new alpha2-adrenoceptor agonist in mice.
TLDR
PT-31, which is chemically related to 3-benzyl-imidazolidine, is presented with an analgesic profile that results from alpha(2)-adrenoceptor activation, and the combination of morphine and PT-31 produced greater antinociceptive activity than either alone and isobolographic analysis revealed a synergistic interaction between these compounds. Expand
Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives.
TLDR
A series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction, and cell viability was analysed using a 3-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Expand
Increased Serum Interleukin 22 in Patients with Rheumatoid Arthritis and Correlation with Disease Activity
TLDR
Elevated serum IL-22 allows discrimination between patients with different clinical and laboratory measures and indicates the potential of IL- 22 as an additional tool for assessment of activity in RA, particularly in patients with RF antibodies and longterm disease. Expand
Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities.
TLDR
New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model and the hypoglycemic and hypolipidemic activities of compounds were compared with the result of their docking after removal of the co-crystallized ligand present in the 2PRG structure. Expand
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