S. Gaffen

Publications252
h-index66
Citations18,010
Highly Influential Citations779
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Structure and signalling in the IL-17 receptor family
  • S. Gaffen
  • Biology, Medicine
    Nature Reviews Immunology
  • 3 July 2009
TLDR
Research defining the signal transduction pathways induced by IL-17R family cytokines has lagged behind that of other cytokine families, but studies in the past 2 years have begun to delineate unusual functional motifs and new proximal signalling mediators used by the IL- 17R family to mediate downstream events.
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
TLDR
This Review focuses on the recent advances that have been made regarding the transcriptional control of TH 17 cell plasticity and stability, as well as the effector functions of TH17 cells, and highlights the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues.
Structure and signalling in the IL-17 receptor family
  • S. Gaffen
  • Medicine
    Nature Reviews Immunology
  • 1 October 2009
Nature Reviews Immunology 9, 556–567 (2009); published online 3 July 2009; corrected after print 7 August 2009 In the version of this article initially published, reference 22 was incorrectly stated…
Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
TLDR
The Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors.
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
TLDR
It is proposed that vaccination induces IL-17-producing CD4+ T cells that populate the lung and, after challenge, trigger the production of chemokines that recruit CD4- T cells producing interferon-γ, which ultimately restrict bacterial growth.
Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease
TLDR
The major IL‐17 target genes that mediate this cytokine’s activities in both autoimmune and chronic diseases as well as during various types of infections are summarized.
An overview of IL-17 function and signaling.
1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
TLDR
In vivo treatment of mice with ongoing experimental autoimmune encephalomyelitis diminishes paralysis and progression of the disease and reduces IL-17A-secreting T cells in the periphery and central nervous system (CNS).
The IL-17 Family of Cytokines in Health and Disease.
Overview of interleukin-2 function, production and clinical applications.
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